Product Name	PCDH7
Chinese Name	原钙粘蛋白7抗体
Alias	BH Pcdh; BH protocadherin; BH-Pcdh; BHPCDH; Brain heart protocadherin; Brain-heart protocadherin; PCDH 7; PCDH7; PCDH-7; PCDH7_HUMAN; Protocadherin 7; Protocadherin7; Protocadherin-7.
Research Area	Neurobiology  Signal transduction  Cell adhesion molecule  Cytoskeleton  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	113kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PCDH7: 431-530/1069 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	As a subfamily of the cadherin superfamily, protocadherins are cadherin-like cell adhesion proteins that contain up to seven extracellular domains and are predominantly expressed in the nervous system. Importantly, the adhesion mechanism of protocadherins is distinct from classic cadherins. Through inactivation or overexpression, several protocadherins have been implicated in a variety of cancers. PCDH7 (protocadherin 7), also known as BHPCDH or BH-Pcdh, is a 1069 amino acid single-pass I membrane protein that is expressed in the brain and heart. Containing seven cadherin domains, PCDH7 is thought to function in cell-cell recognition and adhesion. PCDH7 exists as three isoforms due to alternative splicing events. Function: Expressed predominantly in brain and heart and at lower levels in various other tissues. Subcellular Location: Cell membrane. Post-translational modifications: Isoform C is phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 7 cadherin domains. SWISS: O60245 Gene ID: 5099 Database links: Entrez Gene: 488843 Dog Entrez Gene: 5099 Human Entrez Gene: 54216 Mouse Omim: 602988 Human SwissProt: O60245 Human Unigene: 479439 Human
Product Picture	Sample: Hela(Human) Cell Lysate at 30 ug HepG2(Human) Cell Lysate at 30 ug MCF-7(Human) Cell Lysate at 30 ug NIH/3T3(Mouse) Cell Lysate at 30 ug Primary: Anti- PCDH7 (SL11085R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 113 kD Observed band size: 150 kD Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PCDH7) Polyclonal Antibody, Unconjugated (SL11085R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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