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Product Name CNTNAP4 Chinese Name 接触蛋白相关蛋白4抗体 Alias CASPR 4; CASPR4; Cell recognition molecule Caspr4; Cell recognition protein CASPR4; CNTNAP 4; CNTP4_HUMAN; Contactin associated protein like 4; Contactin-associated protein-like 4. literatures Specific References (1) | SL11076R has been referenced in 1 publications.[IF=8.063] Zhang W et al. CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes. Theranostics. 2020 Feb 10;10(7):3000-3021. ICC ; mouse.Research Area Neurobiology Cell adhesion molecule Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, ) Applications ELISA=1:5000-10000 Flow-Cyt=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 143kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CNTNAP4: 151-250/1308 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and CASPR (neurexin IV). CASPR4 (contactin associated protein-like 4), also known as CNTNAP4, is a 1,308 amino acid single-pass type I membrane protein belonging to the neurexin family. Possibly a cell adhesion protein, CASPR4 is expressed in multiple regions of the brain such as olfactory bulb, hippocampus and deep cerebellar nuclei, with highest expression found in spinal cord, substantia nigra and subthalamic nucleus. CASPR4 is expressed at moderate levels in fetal brain, with low expression in adult testis. Encoded by a gene that maps to human chromosome 16q23.1, CASPR4 contains four laminin G-like domains, a F5/8 type C domain, two EGF-like domains and a single fibrinogen C-terminal domain.
Subcellular Location:
Membrane.
Similarity:
Belongs to the neurexin family.
Contains 2 EGF-like domains.
Contains 1 F5/8 type C domain.
Contains 1 fibrinogen C-terminal domain.
Contains 4 laminin G-like domains.
SWISS:
Q9C0A0
Gene ID:
85445
Database links:
Product Picture Blank control:U937.
Primary Antibody (green line): Rabbit Anti-CNTNAP4 antibody (SL11076R)
Dilution: 2μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG .
Secondary Antibody : Goat anti-rabbit IgG-PE
Dilution: 1μg /test.
Protocol
The cells wereincubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
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