Product Name	SPON2
Chinese Name	Extracellular matrix底物反应蛋白2抗体
Alias	M spondin; Mindin; SPON 2; Differentially expressed in cancerous and non-cancerous lung cells 1; DIL 1; DIL-1; DIL1; M spondin; Mindin; Spon2; SPON2_HUMAN; Spondin 2; Spondin-2.
literatures	Specific References  (1)     |     SL11064R has been referenced in 1 publications. [IF=11.161] Huang, Chengmei. et al. Tumor cell-derived SPON2 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by activating PYK2 in CRC. J Exp Clin Canc Res. 2021 Dec;40(1):1-17  IHC ;  human.   PubMed:34583750
Research Area	Neurobiology  Signal transduction  Cell adhesion molecule  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SPON2_HUMAN: 21-120/331
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Thrombospondin proteins, Thrombospondins 1-4 and Thrombospondin 5 (also designated COMP), compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Spondin-2, or Mindin, is also designated DIL-1 for its differential expression in cancerous and non-cancerous lung cells. Full-length SPON2 cDNA encodes a 331 amino acid protein with a domain arrangement similar to zebrafish F-Spondin and Mindin-1/Mindin-2: an FS1 domain, an FS2 domain, a hydrophobic signal sequence in the N-terminus and a Thrombospondin type I repeat. Immunoblot analysis demonstrates expression of dimers and oligomers in a concentration-dependent manner under nonreducing conditions. Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). Subunit: Monomer. Interacts with integrin. Subcellular Location: Secreted; extracellular space; extracellular matrix. Tissue Specificity: Expressed in normal lung tissue but not in lung carcinoma cell lines. Similarity: Contains 1 spondin domain. Contains 1 TSP type-1 domain. SWISS: Q9BUD6 Gene ID: 10417 Database links: Entrez Gene: 10417 Human Entrez Gene: 100689 Mouse Entrez Gene: 171569 Rat Omim: 605918 Human SwissProt: Q9BUD6 Human SwissProt: Q8BMS2 Mouse SwissProt: Q9WV75 Rat Unigene: 302963 Human Unigene: 635350 Human Unigene: 34694 Mouse Unigene: 6699 Rat

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