Product Name	Plakophilin 2
Chinese Name	桥粒斑菲素蛋白2抗体
Alias	ARVD 9; ARVD-9; ARVD9; PKP 2; PKP2; PKP-2; Plakophilin-2. Plakophilin2; PKP2_HUMAN.
literatures	Specific References  (1)     |     SL11063R has been referenced in 1 publications. [IF=5.08] Akdis, Deniz, et al. "Myocardial Expression Profiles of Candidate Molecules in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia compared to Dilated Cardiomyopathy and Healthy Controls." Heart Rhythm (2015).  IHC-P ;  Human.   PubMed:26569459
Research Area	Cardiovascular  Neurobiology  Cell adhesion molecule  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	97kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Plakophilin 2: 801-881/881
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains, and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin-1 mediates increases in desmosomal protein content, desmosome assembly, and regulation of cell migration. Plakophilin-2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin-3 plays a role in both desmosome-dependent adhesion and signaling pathways. Plakophilin-4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function. Function: May play a role in junctional plaques. Subunit: Interacts with DSC2. Subcellular Location: Nucleus. Cell junction, desmosome.Note=Nuclear and associated with desmosomes. Tissue Specificity: Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9) [MIM:609040]; also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Similarity: Belongs to the beta-catenin family. Contains 8 ARM repeats. SWISS: Q99959 Gene ID: 5318 Database links: Entrez Gene: 537784 Cow Entrez Gene: 486613 Dog Entrez Gene: 101150898 Gorilla Entrez Gene: 101830795 Hamster Entrez Gene: 100070065 Horse Entrez Gene: 5318 Human Entrez Gene: 67451 Mouse Entrez Gene: 100347738 Rabbit Entrez Gene: 287925 Rat Omim: 602861 Human SwissProt: Q99959 Human Unigene: 164384 Human Unigene: 2252 Mouse Unigene: 27944 Rat
Product Picture	Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Plakophilin 2 Polyclonal Antibody, Unconjugated(SL11063R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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Totalgoods,subtotals:￥Checkout