Product Name	DNAH10
Chinese Name	轴丝动力蛋白10抗体
Alias	axonemal; Axonemal beta dynein heavy chain 10; Ciliary dynein heavy chain 10; DNAH10; DYH10_HUMAN; Dynein heavy chain 10; KIAA2017.
literatures	Specific References  (2)     |     SL11022R has been referenced in 2 publications. [IF=11.025] Chaofeng Tu. et al. Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice. Am J Hum Genet. 2021 Jul;:  IF ;  Human.   PubMed:34237282 [IF=10.849] Lu, Shuai. et al. Bi-allelic variants in human WDR63 cause male infertility via abnormal inner dynein arms assembly. Cell Discov. 2021 Nov;7(1):1-15  WB ;  Mouse.   PubMed:34782613
Research Area	Neurobiology  Signal transduction  Cell adhesion molecule  Cytoskeleton  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	515kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DNAH10: 3561-3700/4471
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008] Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain. Subunit: Consists of at least two heavy chains and a number of intermediate and light chains. Subcellular Location: Cytoplasm. cytoskeleton. cilium axoneme. Tissue Specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart. Similarity: Belongs to the dynein heavy chain family. Contains 5 TPR repeats. SWISS: Q8IVF4 Gene ID: 196385 Database links: Entrez Gene: 196385 Human Omim: 605884 Human SwissProt: Q8IVF4 Human Unigene: 622654 Human

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