Product Name	ESYT1
Chinese Name	延伸突触蛋白1抗体
Alias	Extended synaptotagmin 1; KIAA0747; E Syt1; E-Syt1; Esyt1; ESYT1_HUMAN; Extended synaptotagmin like protein 1; Extended synaptotagmin-1; Family with sequence similarity 62 (C2 domain containing) member A; Family with sequence similarity 62 member A; MBC2; Membrane bound C2 domain containing protein; Membrane-bound C2 domain-containing protein; Protein FAM62A.
Research Area	Cell biology  immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Monkey, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	123kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ESYT1/FAM62A: 651-750/1104
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. The FAM62A gene product has been provisionally designated FAM62A pending further characterization. Function: May play a role as calcium-regulated intrinsic membrane protein. Subcellular Location: Membrane. Localizes to intracellular membranes. Tissue Specificity: Widely expressed. Similarity: Belongs to the extended synaptotagmin family. Contains 5 C2 domains. SWISS: Q9BSJ8 Gene ID: 23344 Database links: Entrez Gene: 23344 Human Entrez Gene: 520669 Cow Entrez Gene: 100051975 Horse Entrez Gene: 23943 Mouse Entrez Gene: 100343457 Rabbit Entrez Gene: 29579 Rat SwissProt: Q9BSJ8 Human SwissProt: Q3U7R1 Mouse SwissProt: Q5RAG2 Orangutan SwissProt: Q9Z1X1 Rat Unigene: 632729 Human Unigene: 66056 Mouse Unigene: 11636 Rat
Product Picture	Sample: 293T(Human) Cell Lysate at 40 ug Primary: Anti-ESYT1 (SL11002R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 123 kD Observed band size: 123 kD Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ESYT1) Polyclonal Antibody, Unconjugated (SL11002R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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