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Product Name HRH4 Chinese Name 组织胺H4受体抗体 Alias GPCR105; GPRv53; H4 antibody H4R; HH4R; Histamine H4 receptor; AXOR35; BG26; G protein coupled receptor 105; HRH4_HUMAN; SP9144. literatures Specific References (2) | SL10993R has been referenced in 2 publications.[IF=6.986] Bando, Kanan. et al. Histamine acts via H4-receptor stimulation to cause augmented inflammation when lipopolysaccharide is co-administered with a nitrogen-containing bisphosphonate. INFLAMM RES. 2022 Oct;:1-15 IHC ; Mouse.[IF=6.038] Liao, Xiaodan. et al. Fullerene nanoparticles for the treatment of ulcerative colitis. 2021 Nov 02 WB ; Rat.Research Area Tumour immunology Signal transduction Apoptosis transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 44kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse HRH4: 101-200/391 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Function:
The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist)
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q91ZY2
Gene ID:
225192
Database links:Entrez Gene: 59340 Human
Entrez Gene: 225192 Mouse
Omim: 606792 Human
SwissProt: Q9H3N8 Human
SwissProt: Q91ZY2 Mouse
Unigene: 287388 Human
Unigene: 207073 Mouse
Unigene: 162272 Rat
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