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Product Name ANGPTL6 Chinese Name 血管生成素相关蛋白6抗体 Alias ARP5; AGF; Angiopoietin like 6; Angiopoietin like Protein 6; Angiopoietin related Growth Factor; Angiopoietin related protein 5; Angiopoietin-like protein 6; Angiopoietin-related growth factor; Angiopoietin-related protein 5; Angiopoietin-related protein 6; ANGL6_HUMAN; Angptl6; ARP5. Research Area Cardiovascular Cell biology vascular endothelial cell Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 49kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ANGPTL6: 371-470/470 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Angptl6 (angiopoietin-like 6) is a 470 amino acid secreted protein that contains one fibrinogen C-terminal domain and is a member of the angiopoietin-like family. Expressed abundantly in liver and present at lower levels in testis, kidney, heart, brain and lung, Angptl6 plays a role in wound healing and is also thought to promote neovascularization and enhance the chemotactic activity of endothelial cells. Additionally, Angptl6 may be involved in epidermal proliferation, remodeling and regeneration and may be able to counteract obesity by increasing energy expenditure. Human Angptl6 shares 74% amino acid identity with its mouse counterpart, suggesting a conserved role between species. The gene encoding Angptl6 maps to human chromosome 19, which is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).
Function:
May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure.
Subcellular Location:
Secreted (Probable).
Similarity:
Contains 1 fibrinogen C-terminal domain.
SWISS:
Q8NI99
Gene ID:
83854
Database links:Entrez Gene: 83854 Human
Entrez Gene: 70726 Mouse
Omim: 609336 Human
SwissProt: Q8NI99 Human
SwissProt: Q8R0Z6 Mouse
Unigene: 712850 Human
Unigene: 34019 Mouse
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