Product Name	CCR-2
Chinese Name	细胞表面Chemokine受体2抗体
Alias	C-C Chemokine receptor 2B; C C chemokine receptor type 2; C C CKR 2; CC chemokine receptor type 2; CC CKR 2; CCCKR2; CCR 2; CCR1L; CCR2A; CCR2B; CCR5L; CD192; CD192 antigen; Chemokine C C motif receptor 2; Chemokine CC Motif Receptor 2; CKR 2; CKR2; CKR2A; CKR2B; CMKBR2; MCP 1 R; MCP1 RECEPTOR; MCP1R; Monocyte chemoattractant protein 1 receptor; Monocyte Chemotactic Protein 1 Receptor; CCR2_HUMAN; C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR2; Monocyte chemoattractant protein 1 receptor; MCP-1-R.
Research Area	immunology  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse CCR-2: 1-42/373 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]. Function: Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Subunit: Binds to HIV-1 Tat. Interacts with ARRB1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: N-glycosylated. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P41597 Gene ID: 12772 Database links: Entrez Gene: 729230 Human Entrez Gene: 12772 Mouse Entrez Gene: 60463 Rat Omim: 601267 Human SwissProt: P41597 Human SwissProt: P51683 Mouse SwissProt: O55193 Rat Unigene: 511794 Human Unigene: 705362 Human Unigene: 6272 Mouse Unigene: 211983 Rat
Product Picture	Blank control (blue line): Hela (fixed with 80% methanol for 5 min at -20℃ ). Primary Antibody (green line): Rabbit Anti- CCR-2 antibody (SL10963R),Dilution: 0.2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test.

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