Product Name	CHI3L1
Chinese Name	软骨glycoprotein39抗体
Alias	CHI3L1; 39 kDa synovial protein; ASRT7; Cartilage glycoprotein 39; CGP39; chitinase 3 like 1 (cartilage glycoprotein 39); chitinase 3 like 1; Chitinase 3 like protein 1 precursor; chitinase; GP 39; GP39; HC gp39; HCGP 3P; HCgp39; YKL 40; YKL40; CGP-39; CH3L1_HUMAN; chitinase 3 like 1; Chitinase-3-like protein 1 hCGP-39; YKL-40; YYL 40.
literatures	Specific References  (4)     |     SL1093R has been referenced in 4 publications. [IF=16.494] Wang et al. Clara cell 10-kD protein suppresses chitinase 3-like 1 expression associated with eosinophilic chronic rhinosinusitis. (2010) Am.J.Respir.Crit.Care.Med. 181:908-16  IHC ;  Mouse&Human.   PubMed:20093645 [IF=3.41] Tanaka, Yuki, et al. "Antigen‐specific overexpression of human cartilage glycoprotein 39 on CD4+ CD25+ Foxp3+ Treg cells in the generation of glucose‐6‐phosphate isomerase induced arthritis." Clinical & Experimental Immunology (2014).  Mouse.   PubMed:24730590 [IF=3.265] Zheng et al. Establishment of using serum YKL-40 and SCCA in combination for the diagnosis of patients with esophageal squamous cell carcinoma. (2014) BMC.Cance. 14:490  WB,IHC-P ;  Human.   PubMed:25001061 [IF=1.29] Ben, Su-qin, et al. "Ovalbumin enhances YKL-40, IL-5, GM-CSF, and eotaxin expression simultaneously in primarily cultured mouse tracheal epithelial cells." In Vitro Cellular & Developmental Biology-Animal (2013): 1-8.  WB ;  Mouse.   PubMed:24142153
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from rat CHI3L1: 330-381/381
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] Function: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment. Subunit: Monomer. Subcellular Location: Secreted, extracellular space. Tissue Specificity: Present in articular chondrocytes, synovial cells as well as in liver. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. Similarity: Belongs to the glycosyl hydrolase 18 family. SWISS: Q9WTV1 Gene ID: 89824 Database links: Entrez Gene: 1116 Human Entrez Gene: 12654 Mouse Entrez Gene: 396865 Pig Entrez Gene: 89824 Rat Omim: 601525 Human SwissProt: P36222 Human SwissProt: Q61362 Mouse SwissProt: Q5RBP6 Orangutan SwissProt: Q29411 Pig SwissProt: Q9WTV1 Rat Unigene: 382202 Human Unigene: 38274 Mouse Unigene: 68940 Rat
Product Picture	Protein: Liver(Rat) lysate at 30ug; Colon carcinoma(Human) lysates at 30ug; Primary: Anti-CGP-39/CHI3L1/YKL-40 (SL1093R) at 1:200; Secondary: HRP conjugated Goat Anti-Rabbit IgG(SL0295G-HRP) at 1: 3000; Predicted band size : 42kD Observed band size : 39kD Sample: Lane 1: Mouse Lung tissue lysates Lane 2: Rat Lung tissue lysates Primary: Anti-CHI3L1 (SL1093R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kDa Observed band size: 42 kDa Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CGP-39/ CHI3L1/YKL-40 Polyclonal Antibody, Unconjugated(SL1093R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human endometrium carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CGP-39/ CHI3L1/YKL-40 Polyclonal Antibody, Unconjugated(SL1093R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human endometrium carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CGP-39/YKL-40 Polyclonal Antibody, Unconjugated(SL1093R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining U87MG cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum, C-0005) at 37°C for 20 min; Antibody incubation with (CHI3L1) polyclonal Antibody, Unconjugated (SL1093R) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue, C02-04002) was used to stain the cell nuclei.

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