Product Name	CCBL1
Chinese Name	谷氨酰胺转胺酶K抗体
Alias	Beta lyase; Beta lysase, kidney; CCBL 1; Cysteine conjugate beta lyase; Cysteine conjugate beta lyase, cytoplasmic; Cysteine conjugate beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); Cysteine S conjugate beta lyase; Cytoplasmic cysteine conjugate beta lyase; FLJ95217; Glutamine phenylpyruvate aminotransferase; Glutamine transaminase K; GTK; KAT1; KATI; Kyneurenine aminotransferase; Kynurenine aminotransferase I; Kynurenine oxoglutarate transaminase 1; MGC29624; OTTHUMP00000022311; OTTHUMP00000022312; KAT1_HUMAN.
Research Area	Tumour  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CCBL1: 201-300/422
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Subunit: Homodimer. Subcellular Location: Cytoplasm. Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. SWISS: Q16773 Gene ID: 883 Database links: Entrez Gene: 883 Human Omim: 600547 Human SwissProt: Q16773 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CCBL1) Polyclonal Antibody, Unconjugated (SL10939R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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