Product Name	SOD2
Chinese Name	超氧化物歧化酶2抗体
Alias	IPO B; Manganese SOD; Superoxide Dismutase 2; Manganese superoxide dismutase; Mn SOD; MNSOD; SOD 2; SOD-2; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn] mitochondrial precursor; Superoxide dismutase 2 mitochondrial; SODM_HUMAN.
literatures	Specific References  (19)     |     SL1080R has been referenced in 19 publications. [IF=6.208] Qiyang Yao. et al. Oxidative Stress as a Contributor to Insulin Resistance in the Skeletal Muscles of Mice with Polycystic Ovary Syndrome. INT J MOL SCI. 2022 Jan;23(19):11384  WB ;  Mouse.   PubMed:36232686 [IF=6.1] Yun, Yang, et al. "Sulfate Aerosols Promote Lung Cancer Metastasis by Epigenetically Regulating the Epithelial-to-Mesenchymal Transition (EMT)." Environmental Science & Technology (2017).  WB ;  Human.   PubMed:28901751 [IF=6.081] Naoki Yoshida. et al. Relationship between Cognitive Dysfunction and Age-Related Variability in Oxidative Markers in Isolated Mitochondria of Alzheimer’s Disease Transgenic Mouse Brains. Biomedicines. 2022 Feb;10(2):281  WB ;  Mouse.   PubMed:10.3390/biomedicines10020281 [IF=6.064] Mengni Bao. et al. N-Acetylcysteine, an ROS Inhibitor, Alleviates the Pathophysiology of Hyperthyroidism-Induced Cardiomyopathy via the ROS/Ca2+ Pathway. BIOMOLECULES. 2022 Sep;12(9):1195  WB ;  Mouse, Rat.   PubMed:10.3390/biom12091195 [IF=6.025] Xuliang Zhang. et al. PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity. FOOD CHEM TOXICOL. 2022 Jun;164:113078  WB ;  Mouse.   PubMed:35489469 [IF=5.279] Lei Wang. et al. Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson’s Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder. J Agr Food Chem. 2022;70(4):1163–1173  WB ;  Mouse.   PubMed:35067061 [IF=5.23] Zhao, Yong, et al. "Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways." Scientific Reports 6 (2016): 37884.  WB ;  Pig.   PubMed:27883089 [IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017).  IHC-P ;  Mouse.   PubMed:29202267 [IF=4.2] Yuan, Qing, et al. "Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity." International Journal of Nanomedicine 9 (2014): 4829.  WB ;  Mouse.   PubMed:25378924 [IF=3.85] Wang, Yandi, et al. "Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis." Toxicology and Applied Pharmacology (2016).  IHC-P ;  Sheep.   PubMed:27815134 [IF=3.647] Lin D et al. Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion. Life Sci . 2020 Jul 15;253:117705.  IHC,WB ;  mouse.   PubMed:32334008 [IF=3.47] Minjeong Kim. et al. Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress. Biomol Ther. 2021 Mar 1; 29(2): 205–210  WB ;  Human.   PubMed:33024059 [IF=3.038] Lan Yang et al. The Involvement of Mitochondrial Biogenesis in Selenium Reduced Hyperglycemia-Aggravated Cerebral Ischemia Injury. Neurochem Res. 2020 Aug;45(8):1888-1901.  WB ;  Mouse.   PubMed:32447509 [IF=2.884] Faria AVS et al. LMWPTP modulates the antioxidant response and autophagy process in human chronic myeloid leukemia cells. Mol Cell Biochem. 2020 Mar;466(1-2):83-89.  WB ;  Human.   PubMed:32016696 [IF=2.721] Yang, Ke. et al. Comparisons between needle puncture and chondroitinase ABC to induce intervertebral disc degeneration in rabbits. EUR SPINE J. 2022 Jun;:1-13  WB ;  Rabbit.   PubMed:35739423 [IF=2.21] Khan, Md Asaduzzaman, et al. "Regulatory effects of resveratrol on antioxidant enzymes: A mechanism of growth inhibition and apoptosis induction in cancer cells." Molecules and cells (2013): 1-7.  WB ;  Human.   PubMed:23456297 [IF=1.832] Gao J et al. Proteomic Analyses of Mammary Glands Provide Insight into the Immunity and Metabolism Pathways Associated with Clinical Mastitis in Meat Sheep.Animals (Basel). 2019 May 31;9(6). pii: E309.  WB ;  Sheep.   PubMed:31159303 [IF=0] Hermawati E et al. Spatial Memory Disturbance Following Transient Brain Ischemia is Associated with Vascular Remodeling in Hippocampus. Kobe J Med Sci. 2018 Oct 15;64(3):E93-E106.  IHC-P ;  Rat.   PubMed:30666039 [IF=0] SUKADANA IM et al. The Intake of Inocarpus Fagiferus Fosb Stem Bark N-Buthanol Extract Caused the Increase Expression of Sod-2 and Sod-3 Aortic Endhotelial Cells of Hypercholesterolemia Rats. Biomedical and Pharmacology Journal.2017, 10(4):1773-1777 ·  WB ;  Rat.   PubMed:doi:10.13005/bpj/1291
Research Area	Neurobiology  Apoptosis  Kinases and Phosphatases  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SOD2: 41-78/222
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] Function: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Subunit: Homotetramer. Subcellular Location: Mitochondrion matrix. Post-translational modifications: Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. DISEASE: Microvascular complications of diabetes 6 (MVCD6) [MIM:612634]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Similarity: Belongs to the iron/manganese superoxide dismutase family. SWISS: P04179 Gene ID: 6648 Database links: Entrez Gene: 374042 Chicken Entrez Gene: 281496 Cow Entrez Gene: 476258 Dog Entrez Gene: 6648 Human Entrez Gene: 20656 Mouse Entrez Gene: 100154319 Pig Entrez Gene: 24787 Rat Omim: 147460 Human SwissProt: P41976 Cow SwissProt: P04179 Human SwissProt: P09671 Mouse SwissProt: P41982 Rabbit SwissProt: P07895 Rat Unigene: 487046 Human Unigene: 290876 Mouse Unigene: 10488 Rat SOD2是清除Mitochondrion氧自由基的最主要的酶类，SOD2参与促进Cell differentiation和Tumour发生。SOD2的表达缺乏与血管病变、新生儿致死、神经退行性病变有关联。SOD2过度表达与抵御细胞氧化损伤有关。 超氧化物歧化酶又称(Superoxide dismutase，简称SOD)是参与机体抗氧化（ROS，反应性氧离子reactive oxygen species）防御机制和抵御细胞氧化损伤最重要的酶类之一， 广泛存在于需氧生物、耐氧生物及某些厌氧微生物中，目前已知的SOD 主要分为三类，即胞质中Cu/Zn-SOD（即SOD1）、Mitochondrion中的Mn-SOD（即SOD2）和ec-SOD(即SOD3)。
Product Picture	Sample: Heart(Mouse) lysate at 30ug; Primary: Anti-SOD2 (SL1080R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G-HRP) at 1: 5000 dilution; Predicted band size :22kD Observed band size : 19kD

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