Product Name	GARS
Chinese Name	X连锁Charcot-Marie-Tooth神经病变相关蛋白抗体
Alias	AP 4 A synthetase; Charcot Marie Tooth neuropathy 2D; Charcot Marie Tooth neuropathy neuronal type D; CMT2D; Diadenosine tetraphosphate synthetase; DSMAV; EC 6.1.1.14; Glycine tRNA ligase; Glycyl tRNA synthetase; GlyRS; HMN5; SMAD1.
Research Area	Cell biology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	83kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GARS: 201-300/739
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. [provided by RefSeq, Jul 2008] Function: GARS synthetase catalyzes the ligation of glycine with glycyl-tRNA using ATP and its mutation induces Charcot-Marie-Tooth (CMT) disease. Subcellular Location: Cytoplasmic. SWISS: P41250 Gene ID: 2617 Database links: Entrez Gene: 2617 Human Entrez Gene: 353172 Mouse Entrez Gene: 297113 Rat Omim: 600287 Human SwissProt: P41250 Human SwissProt: Q9CZD3 Mouse SwissProt: Q5I0G4 Rat Unigene: 404321 Human Unigene: 3338 Rat

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