Product Name	COLEC12
Chinese Name	凝集胎盘蛋白1抗体
Alias	Collectin placenta protein 1; Collectin placenta 1; Collectin-12; hCL-P1; CL-P1; Nurse cell scavenger receptor; Scavenger receptor with C-type lectin; Scavenger receptor class A member 4; COLEC12; CLP1; NSR2; SCARA4; SRCL. COL12_HUMAN.
Research Area	Cell biology  Chromatin and nuclear signals
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human COLEC12: 31-130/742 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Colec12 is a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. Colec12 is a scavenger receptor that displays several functions associated with host defense. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast and mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Function: Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease. Subunit: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid peptide. Subcellular Location: Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface. Tissue Specificity: Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient. Similarity: Contains 1 C-type lectin domain. Contains 3 collagen-like domains. SWISS: Q5KU26 Gene ID: 81035 Database links: Entrez Gene: 421061 Chicken Entrez Gene: 504741 Cow Entrez Gene: 81035 Human Entrez Gene: 140792 Mouse Entrez Gene: 361289 Rat Omim: 607621 Human SwissProt: Q2LK54 Chicken SwissProt: A6QP79 Cow SwissProt: Q5KU26 Human SwissProt: Q8K4Q8 Mouse SwissProt: Q4V885 Rat Unigene: 33741 Chicken Unigene: 4492 Cow Unigene: 464422 Human Unigene: 218571 Mouse Unigene: 31273 Rat

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