Product Name	C9orf127
Chinese Name	鼻咽癌细胞相关基因6抗体
Alias	NGX6; 4930500O05Rik; C9orf127; MGC120460; NAG-5; NGX6; RGD1310012; RP11-112J3.10; TMEM8B; nasopharyngeal carcinoma; NPC associated gene 6; TMM8B_HUMAN; chromosome 9 open reading frame 127; NAG 5; Nasopharyngeal carcinoma expressed 6; Nasopharyngeal carcinoma related protein; Nasopharyngeal carcinoma-associated gene 6 protein; Protein NAG-5; Protein NGX6; RP11-112J3.10; RP11-112J3.10-001; TMEM8B; Transmembrane protein 8B .
Research Area	Tumour  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NGX6: 21-120/472
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NGX6 (nasopharyngeal carcinoma/NPC associated gene 6) may function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. [SUBUNIT] Isoform 2 (via its cytoplasmic part) interacts with EZR. [SUBCELLULAR LOCATION] Isoform 2: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasm (Probable). Nucleus (Probable). Mitochondrion. Endoplasmic reticulum. Belongs to the NGX6 family. The down-regulation of C9orf127 may be closely associated with tumorigenesis and metastasis of colorectal carcinoma. However, it may not contribute to the development and progression of gastric carcinoma. Function: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. Subunit: Isoform 2 (via its cytoplasmic part) interacts with EZR. Subcellular Location: Cell membrane. Cytoplasm. Nucleus. Mitochondrion. Endoplasmic reticulum. Also detected in mitochondrion and endoplasmic reticulum. Post-translational modifications: Isoform 2 is N-glycosylated. Similarity: Belongs to the TMEM8 family. Contains 1 EGF-like domain. SWISS: A6NDV4 Gene ID: 51754 Database links: Entrez Gene: 51754 Human Entrez Gene: 100125302 Cow Entrez Gene: 242409 Mouse Entrez Gene: 313490 Rat SwissProt: A6QLK4 Cow SwissProt: A6NDV4 Human SwissProt: B1AWJ5 Mouse Unigene: 493808 Human Unigene: 171489 Mouse NGX6是鼻咽癌发生和发展重要的相关蛋白,NGX-6作用于鼻咽癌细胞，抗体可用于鼻咽癌诊断。有学者认为：NGX6也表达在部分消化系统的Tumour中。
Product Picture	Tissue/cell: human nasopharyngeal carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-NGX6/C9orf127 Polyclonal Antibody, Unconjugated(SL1065R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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