Product Name	LIF
Chinese Name	白血病抑制因子抗体
Alias	Leukemia inhibitory factor; DIA; CDF; Cholinergic Differentiation Factor; D factor; differentiation inhibitory activity; Differentiation stimulating factor; Emfilermin; HILDA; Human interleukin in DA cells; LIF_HUMAN; Melanoma derived LPL inhibitor; Melanoma-derived LPL inhibitor; MLPLI.
literatures	Specific References  (7)     |     SL1058R has been referenced in 7 publications. [IF=6.291] Peng Zheng. et al. Alleviative effect of melatonin on the decrease of uterine receptivity caused by blood ammonia through ROS/NF-κB pathway in dairy cow. Ecotox Environ Safe. 2022 Feb;231:113166  WB ;  Bovine.   PubMed:35030520 [IF=3.69] Kiyoshi Terawaki. et al. The ameliorating effects of tokishakuyakusan in a rat model of implantation failure involves endometrial gland leukemia inhibitory factor and decidualization. J Ethnopharmacol. 2021 Jan;265:113288  IHC ;  Rat.   PubMed:32841695 [IF=3.309] Gulistan Sanem Saribas. et al. Ellagic acid increases implantation rates with its antifibrotic effect in the rat model of intrauterine adhesion. PATHOL RES PRACT. 2023 Jun;246:154499  IHC ;  Rat.   PubMed:37163881 [IF=2.2] Cui, Na, et al. "The Roles of Anandamide, Fatty Acid Amide Hydrolase, and Leukemia Inhibitory Factor on the Endometrium during the Implantation Window." Frontiers in Endocrinology 8 (2017): 268.  IHC-P ;  Human.   PubMed:29085337 [IF=1.785] An J et al. A clinical and basic study of optimal endometrial preparation protocols for patients with infertility undergoing frozen‑thawed embryo transfer. Exp Ther Med . 2020 Sep;20(3):2191-2199.  WB ;  Human.   PubMed:32765695 [IF=1.785] Junxia An. et al. A clinical and basic study of optimal endometrial preparation protocols for patients with infertility undergoing frozen‑thawed embryo transfer. Exp Ther Med. 2020 Sep;20(3):2191-2199  WB ;  Human.   PubMed:32765695 [IF=1.18] Liang, Youde, et al. "Expression of LIF and LIFR in periodontal tissue during orthodontic tooth movement." The Angle Orthodontist 81.4 (2011): 600-608.  IHC-P ;  Rat.   PubMed:21446866
Research Area	Tumour  Cell biology  immunology  Neurobiology  Growth factors and hormones  Cyclin  Cell differentiation  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LIF: 101-202/202
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The leukemia inhibitory factor- LIF is a kind of cell factor that has various living creature functions.It has the leukemia cell of inducement to divide, regulating the growth metabolism of the bone organization, maintaining the basic characteristic of the Embryonicstem celles and promoting the mankind build the blood stem cell to divide to propagate, promote the cholinergic neuron to divide, obstruct the fat cell to synthesize, stimulate the muscle cell growth, regulate the liver cell to expect to respond the egg white to synthesize etc. in the acute the biology activity etc. function. Function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Subcellular Location: Secreted. Similarity: Belongs to the LIF/OSM family. SWISS: P15018 Gene ID: 3976 Database links: Entrez Gene: 3976 Human Entrez Gene: 16878 Mouse Omim: 159540 Human SwissProt: P15018 Human SwissProt: P09056 Mouse Unigene: 2250 Human Unigene: 4964 Mouse Growth factors and hormones（ Growth Factor and Hormones） 白血病抑制因子-LIF是一种具有多种生物功能的cell factor。它具有诱导白血病Cell differentiation，调节骨组织的生长代谢，维持胚胎Stem cells（Embryonicstem celles细胞）的基本特征、促进人类造血Stem cells的分化增殖、促进胆碱能神经元的分化、阻碍脂肪细胞合成、刺激成肌细胞生长、调节肝细胞中急性期反应蛋白的合成等生物学活性等作用.
Product Picture	Sample: Large intestine(mouse) Lysate at 40 ug U87mg cell(human) Lysate at 30 ug Primary: Anti- LIF (SL1058R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 20kD Observed band size: 30/50 kD

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