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Product Name IL24 Chinese Name 白介素-24抗体 Alias IL24_HUMAN; Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein. literatures Specific References (2) | SL10576R has been referenced in 2 publications.[IF=3.202] Yang M et al. Combination therapy with F5/35 fiber chimeric conditionally replicative adenoviruses expressing IL-24 enhances the antitumor effect of temozolomide against melanoma. (2018)Cancer Medicine. Dec;7(12):5928-5942. WB&ICC ;[IF=1.482] Liang et al. A conditionally replicating adenovirus expressing IL-24 acts synergistically with temozolomide to enhance apoptosis in melanoma cells in vitro. (2017) Oncol.Let. 13:4185-4189 WB ; Human.Research Area Tumour immunology cell factor Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 17kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human IL24: 121-206/206 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Function:
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
Subcellular Location:
Secreted (Potential).
Tissue Specificity:
Up-regulated in melanoma cells induced to terminally differentiate.
Similarity:
Belongs to the IL-10 family.
SWISS:
Q13007
Gene ID:
11009
Database links:Entrez Gene: 11009 Human
Omim: 604136 Human
SwissProt: Q13007 Human
Unigene: 58831 Human
Unigene: 728324 Human
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