Product Name	CCL3
Chinese Name	巨噬细胞炎症因子1α抗体
Alias	Tonsillar lymphocyte LD78 alpha protein; CCL 3; CCL3; Chemokine C C motif ligand 3; Chemokine CC Motif Ligand 3; G0/G1 switch regulatory protein 19 1; G0S19 1; G0S19 1 protein; Heparin binding chemotaxis protein antibody L2G25B; LD78ALPHA; Macrophage inflammatory protein 1 alpha; MIP 1 alpha; MIP-1 Alpha; MIP 1A; MIP1A; PAT 464.1; SCYA 3; SCYA3; SIS alpha; SIS beta; Small inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; CCL3_HUMAN;   MIP-1α; MIP-1-α; MIP 1 α; MIP1α; MIP1-α.
literatures	Specific References  (1)     |     SL1045R has been referenced in 1 publications. [IF=4.4] Lee et al. Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis. (2014) Front.Pharmaco. 5:140  Human,Mouse.   PubMed:24966836
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	8kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MIP-1 alpha: 41-92/92
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated. Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). Subunit: Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). Subcellular Location: Secreted. Post-translational modifications: N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: P10147 Gene ID: 6348 Database links: Entrez Gene: 6348 Human Entrez Gene: 20302 Mouse Entrez Gene: 25542 Rat Omim: 182283 Human SwissProt: P10147 Human SwissProt: P10855 Mouse SwissProt: P50229 Rat Unigene: 514107 Human Unigene: 1282 Mouse Unigene: 10139 Rat 巨噬细胞炎症蛋白1α（MIP-1α）是CCChemokine中的一种。主要用于炎症、Tumour方面的研究。
Product Picture	Tissue/cell: rat exfoliated cells; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MIP-1 Alpha/CCL3 Polyclonal Antibody, Unconjugated(SL1045R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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