Product Name	CSF1
Chinese Name	巨噬细胞克隆刺激因子抗体
Alias	MM-CSF; M CSF; MCSF; Macrophage Colony Stimulating Factors; Macrophage Colony Stimulating Factor 1; Colony stimulating factor 1 (macrophage); Colony stimulating factor 1; Colony stimulating factor macrophage specific; CSF 1; CSF-1; Csfm; Lanimostim; Macrophage Colony Stimulating Factor 1; MGC31930; Processed macrophage colony-stimulating factor 1; CSF1_MOUSE; CSF1_HUMAN.
literatures	Specific References  (1)     |     SL1042R has been referenced in 1 publications. [IF=13.281] Yufei Liu. et al. Inflammation-Stimulated MSC-Derived Small Extracellular Vesicle miR-27b-3p Regulates Macrophages by Targeting CSF-1 to Promote Temporomandibular Joint Condylar Regeneration. 2022 Mar 11  WB ;  Human.   PubMed:10.1002/smll.202107354
Research Area	Cell biology  immunology  Developmental biology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60kDa
Cellular localization	The cell membrane Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse MCSF: 461-552/552 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Four distinct colony-stimulating factors (CSFs) that promote survival, proliferation and differentiation of bone marrow precursor cells have been well characterized: granulocyte macrophage CSF (GMCSF), granulocyte CSF (GCSF), macrophage CSF (MCSF), and Interleukin-3 (IL-3, Multi CSF). Both GMCSF and IL-3 are multipotential growth factors, stimulating proliferation of progenitor cells from more than one hematopoietic lineage. In contrast, GCSF and MCSF are lineage restricted hematopoietic growth factors, stimulating final mitotic divisions and the terminal cellular maturation of the partially differentiated hematopoietic progenitors. Macrophage CSF, also known as CSF1, is produced by monocytes, fibroblasts and endothelial cells. It stimulates the formation of macrophage colonies, enhances antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages, and inhibits bone resorption by osetoclasts. Natural human MCSF is a dimeric glycoprotein of 70-90 kD molecular weight, existing in multiple glycosylation forms. It binds to a 165 kD glycoprotein of the receptor tyrosine kinase subclass III, a family that includes the receptors for platelet derived growth factor (PDGF) and stem cell factor (SCF). Function: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Subunit: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R. Subcellular Location: Cell membrane; Single-pass membrane protein. Processed macrophage colony-stimulating factor 1: Secreted, extracellular space. Post-translational modifications: N-glycosylated. The predominant soluble form is a chondroitin sulfate-containing proteoglycan. DISEASE: Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling. SWISS: P09603 Gene ID: 1435 Database links: Entrez Gene: 1435 Human Entrez Gene: 12977 Mouse Entrez Gene: 78965 Rat Omim: 120420 Human SwissProt: P09603 Human SwissProt: P07141 Mouse SwissProt: Q8JZQ0 Rat Unigene: 591402 Human Unigene: 795 Mouse Unigene: 83632 Rat M-CSF是促使造血Cell differentiation成粒细胞与巨噬细胞克隆的重要cell factor,对正常血细胞的形成与造血细胞 的存活、分化、正常造血功能 的维持具有重要作用,直接与间接增加lak细胞的活性,在人体 的cell factor网络中占有重要 的地位,目前广泛应用于化.放疗 的辅助治疗中。 目前研究主要应用在免疫缺陷性疾病及病毒性疾病：慢性肝病,尤其是与病毒相关的疾病,因其发病过程涉及免疫细胞与造血系统,有可能成为gm-csf(粒细胞-巨噬细胞克隆刺激因子)应用的新领域。人和小鼠天然M-CSF为glycoprotein，由二硫键连接的同源双体，分子量40～90kDa。人和小鼠M-CSF分子这个区域结构高度保守，其同源性达80％。
Product Picture	Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MCSF Polyclonal Antibody, Unconjugated(SL1042R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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