Product Name	G-CSF/CSF3
Chinese Name	粒细胞-巨噬细胞集落刺激因子3抗体
Alias	GCSF; Colony stimulating factor 3 (granulocyte); CSF 3; CSF beta; CSF3; Csfg; Filgrastim; GCSA; Granulocyte colony stimulating factor; Lenograstim; Macrophage granulocyte inducer 2; MGC45931; MGI 2; Pluripoietin; Granulocyte Colony Stimulating Factors 3; CSF3_HUMAN.
literatures	Specific References  (8)     |     SL1023R has been referenced in 8 publications. [IF=6.529] Ting Shang. et al. The combination of four main components in Xuebijing injection improved the preventive effects of Cyclosporin A in acute graft-versus-host disease mice by protecting intestinal microenvironment. Biomed Pharmacother. 2022 Apr;148:112675  WB,IHC ;  Mouse.   PubMed:35183993 [IF=5.345] Yuan SJ et al. Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer.J Nanobiotechnology. 2019 Oct 17;17(1):110.  IHC-P ;  Mouse.   PubMed:31623629 [IF=5.177] Wen-Chieh Liao. et al. CHPF promotes malignancy of breast cancer cells by modifying syndecan-4 and the tumor microenvironment. Am J Cancer Res. 2021; 11(3): 812–826  WB,IHC ;  Human.   PubMed:33791155 [IF=5.085] Yi Yang. et al. γδ T/Interleukin-17A Contributes to the Effect of Maresin Conjugates in Tissue Regeneration 1 on Lipopolysaccharide-Induced Cardiac Injury. Front Immunol. 2021; 12: 674542  WB ;  Mouse.   PubMed:33981320 [IF=4.671] Hong L et al. Protective effects of human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2019 Nov 19. pii: mjz105.  WB ;  Mouse.   PubMed:31742349 [IF=4] Hong L et al. Protective effects of Human umbilical cord mesenchymal stem cell-derived conditioned medium on ovarian damage. J Mol Cell Biol. 2020 Jun 11;12(5):372-385.  WB ;  Human.   PubMed:31742349 [IF=3.711] Volkmann J et al. Kidney injury enhances renal G‐CSF expression and modulates granulopoiesis and human neutrophil CD177 in vivo. Clin Exp Immunol. 2019 Sep 11.  IHC-P ;  Human.   PubMed:31509227 [IF=1.44] Kameyama, Hiroshi, et al. "The mRNA Expressions and Immunohistochemistry of Factors Involved in Angiogenesis and Lymphangiogenesis in the Early Stage of Rat Skin Incision Wounds." Legal Medicine (2015).  IHC-P ;  Rat.   PubMed:25794881
Research Area	Tumour  immunology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CSF3: 155-198/207
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins that regulate haematopoietic cell proliferation and differentiation. G-CSF was isolated initially as a factor supporting the growth of colonies of granulocytes in soft agar cultures. Cells of the monocyte/macrophage lineage are among the most prominent sources of G-CSF, but this factor can also be produced by normal cells of mesodermal origin, including vascular endothelial cells, fibroblasts, and mesothelial cells. Production of G-CSF can be induced in vitro in these cells by a wide variety of stimulatory agents, including LPS, TNF, IL-1, IL-3, I L-4, and IFN-Gamma. G-CSF is likely to play a role in the basal regulation of neutrophil production, and also functions as a primary regulatory factor controlling the neutrophil response to inflammatory stimuli. Furthermore, G-CSF exhibits other biological activities besides the proliferative effects, since G-CSF appears to modulate the distribution of neutrophils and progenitor cells within the body. Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Subcellular Location: Secreted. Post-translational modifications: O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells). Similarity: Belongs to the IL-6 superfamily. SWISS: P09919 Gene ID: 1440 Database links: Entrez Gene: 1440 Human Omim: 138970 Human SwissProt: P09919 Human Unigene: 2233 Human Growth factors and hormones（ Growth Factor and Hormones） 集落刺激因子是一组功能很强的骨髓造血细胞增殖因子，GCSF（粒细胞克隆刺激因子）为其中一种，具有刺激粒系母细胞的增殖和分化，并可增强成熟粒细胞功能的作用。粒细胞集落刺激因子在抗感染的非特异性细胞免疫过程中起重要作用。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (G-CSF) Polyclonal Antibody, Unconjugated (SL1023R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human kidney tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CSF3) Polyclonal Antibody, Unconjugated (SL1023R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CSF3) Polyclonal Antibody, Unconjugated (SL1023R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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