Product Name	TLR2
Chinese Name	Toll样受体2（CD282）抗体
Alias	Toll-like receptor 2; Toll like receptor 2; Toll like receptor 2 precursor; Toll-like receptor 2; TLR 2; TLR-2; Toll/interleukin-1 receptor-like protein 4; CD282 antigen; CD282; TIL 4; TIL4; TLR2_HUMAN; Toll/interleukin 1 receptor like 4; Toll/interleukin 1 receptor like protein 4; Toll/interleukin receptor like protein 4.
literatures	Specific References  (33)     |     SL1019R has been referenced in 33 publications. [IF=14.919] Zhang, Peitao. et al. Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors. Nat Commun. 2022 Mar;13(1):1-18  WB ;  Human.   PubMed:35332119 [IF=9.038] Xuting Liu. et al. Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells. J Hazard Mater. 2021 Feb;404:124050  WB,IP ;  Human.   PubMed:33053467 [IF=8.025] Lihui Ni. et al. The combination of insulin and linezolid ameliorates Staphylococcus aureus pneumonia in individuals with diabetes via the TLR2/MAPKs/NLRP3 pathway. INT J BIOL MACROMOL. 2023 Jul;242:124750  WB ;  Mouse.   PubMed:37160172 [IF=6.286] Jianhao Yang. et al. Serum amyloid A regulates TLR2/4-mediated IFN-β signaling pathway against Marek's disease virus. VIRUS RES. 2023 Jan;:199044  WB ;  Chicken.   PubMed:36652973 [IF=6.208] Xu Bai. et al. Toll-like Receptor 2 Is Associated with the Immune Response, Apoptosis, and Angiogenesis in the Mammary Glands of Dairy Cows with Clinical Mastitis. INT J MOL SCI. 2022 Jan;23(18):10717  IHC ;  Bovine.   PubMed:36142648 [IF=5.33] Jing Zhang. et al. Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system. Exp Neurol. 2022 Jan;347:113895  WB ;  Mouse.   PubMed:34653510 [IF=5.227] Zhang J et al. MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis. Neurobiol Dis. 2019 May;125:154-162.  WB ;  Mouse.   PubMed:30707940 [IF=5.1] Xu, Wei, et al. "Glaucocalyxin B Alleviates Lipopolysaccharide-Induced Parkinson’s Disease by Inhibiting TLR/NF-κB and Activating Nrf2/HO-1 Pathway." Cellular Physiology and Biochemistry 44.6 (2017): 2091-2104.  WB ;  Rat.   PubMed:29241205 [IF=4.784] Zhan Q et al. Structural Characterization and Immunomodulatory Activity of a Novel Acid Polysaccharide Isolated from the Pulp of Rosa laevigata Michx Fruit. Int J Biol Macromol. 2019 Nov 12. pii: S0141-8130(19)37108-9.  Other ;  Mouse.   PubMed:31730989 [IF=4.5] Mannic, Tiphaine, et al. "CD14 as a mediator of the Mineralocorticoid Receptor-dependent anti-apolipoproteinA-1 IgG chronotropic effect on cardiomyocytes."Endocrinology (2015): en-2015.  other ;  Rat.   PubMed:26393305 [IF=4.302] Mödinger, Y.et al. C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10. J Cell Mol Med. 2018 Sep 24.  WB&IF ;  Mouse.   PubMed:30247799 [IF=4.181] Yang et al. Sialic acid rescues repurified lipopolysaccharide-induced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis, autophagy, and pyroptosis signaling. (2014) Toxicol.Sci. 141:155-65  WB ;  Rat.   PubMed:24973090 [IF=3.913] Canan Eroğlu Güneş. et al. Glycoside oleandrin downregulates toll-like receptor pathway genes and associated miRNAs in human melanoma cells. GENE. 2022 Aug;:146805  WB ;  Human.   PubMed:35964872 [IF=3.73] Tan, Yan, et al. "Stiffening-Induced High Pulsatility Flow Activates Endothelial Inflammation via a TLR2/NF-κB Pathway." PLoS one 9.7 (2014).  WB ;  Bovine.   PubMed:25029271 [IF=3.524] Rossetto Isabela Maria Urra. et al. Caffeine consumption attenuates ethanol-induced inflammation through the regulation of adenosinergic receptors in the UChB rats cerebellum. Toxicol Res-Uk. 2021 Aug;10(4):835-849  WB ;  Rat.   PubMed:34484675 [IF=3.48] Chen, Xiaoming, et al. ʺSargassum fusiforme polysaccharide activates nuclear factor kappa-B (NF-κB) and induces cytokine production via Toll-like receptors.ʺ Carbohydrate Polymers (2014).  other ;  Rat.   PubMed:24708959 [IF=3.432] Dong W et al. Polychlorinated biphenyl quinone induces caspase 1-mediated pyroptosis through the induction of pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD signal axis. Chem Res Toxicol. 2019 Apr 23.  WB&ICF ;  Human.   PubMed:30977640 [IF=3.37] Xuelian Ma. et al. Down-regulated long non-coding RNA RMST ameliorates dopaminergic neuron damage in Parkinson’s disease rats via regulation of TLR/NF-κB signaling pathway. Brain Res Bull. 2021 Apr;:  WB ;  Rat.   PubMed:33933526 [IF=3.234] Hardigan et al. Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes. (2016) Life.Sci. 159:90-96  IHC ;  Rat.   PubMed:26898123 [IF=2.8] Schimunek, Lukas, et al. "Early decreased TLR2 expression on monocytes is associated with their reduced phagocytic activity and impaired maturation in a porcine polytrauma model." PloS one 12.11 (2017): e0187404.  FCM ;  Pig.   PubMed:29125848 [IF=2.7] Hardigan, Trevor, Yasir Abdul, and Adviye Ergul. "Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes." Life Sciences (2016).  IHC-F ;  Rat.   PubMed:26898123 [IF=2.674] Yao Zheng. et al. Comparative proteomic analysis of spleen reveals key immune-related proteins in the yak (Bos grunniens) at different growth stages. Comp Biochem Phys D. 2022 Jun;42:100968  IHC ;  Yak.   PubMed:35150973 [IF=2.515] Li T et al. Digital gene expression analyses of mammary glands from meat ewes naturally infected with clinical mastitis. R. Soc. open sci. 2019,6: 181604.  WB&IHC-P ;  Sheep.   PubMed:doi:10.1098/rsos.181604 [IF=2.515] Li T et al. Digital gene expression analyses of mammary glands from meat ewes naturally infected with clinical mastitis.R Soc Open Sci. 2019 Jul 3;6(7):181604.  WB&IHC ;  Sheep.   PubMed:31417691 [IF=2.466] I.B. Reis. et al. OncoTherad® (MRB-CFI-1) nano-immunotherapy reduced tumoral progression in non-muscle invasive bladder cancer through activation of Toll-like signaling pathway. Tissue Cell. 2022 Jun;76:101762  IHC ;  Mouse.   PubMed:10.1016/j.tice.2022.101762 [IF=2.276] Zhao Yonglin. et al. Inhibition of Macrophage Migration Inhibitory Factor Protects against Inflammation through a Toll-like Receptor-Related Pathway after Diffuse Axonal Injury in Rats. Biomed Res Int. 2020;2020:5946205  WB ;  Rat.   PubMed:32964038 [IF=2.217] Qi Wang. et al. Effect of oral administration of Limosilactobacillus reuteri on intestinal barrier function and mucosal immunity of suckling piglets. Ital J Anim Sci. 2022;21(1):612-623  WB ;  Piglets.   PubMed:10.1080/1828051X.2022.2048977 [IF=2.02] Tomofuji, Takaaki, et al. "Involvement of toll-like receptor 2 and 4 in association between dyslipidemia and osteoclast differentiation in apolipoprotein E deficient rat periodontium." Lipids in Health and Disease 12.1 (2013): 1.  IHC ;  Rat.   PubMed:23295061 [IF=1.892] Fang Jia. et al. Cytotoxicity and anti-inflammatory effect of a novel diminazene aceturate derivative in bovine mammary epithelial cells. Res Vet Sci. 2021 Jul;137:102  WB ;  Bovine.   PubMed:33964615 [IF=1.709] Barreiros et al. Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice. (2018) J.Appl.Oral.Sci. 26:e20170512  IHC ;  Mice.   PubMed:29995146
Research Area	Tumour  Cardiovascular  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	84kDa
Detection molecular weight	89 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TLR2: 701-784/784 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008] Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Subunit: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Post-translational modifications: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2. Similarity: Belongs to the Toll-like receptor family. Contains 14 LRR (leucine-rich) repeats. Contains 1 TIR domain. SWISS: O60603 Gene ID: 7097 Database links: Entrez Gene: 7097 Human Entrez Gene: 24088 Mouse Entrez Gene: 310553 Rat Omim: 603028 Human SwissProt: O60603 Human SwissProt: Q9QUN7 Mouse Unigene: 519033 Human Unigene: 87596 Mouse Toll样受体2（TLR2）通过激活天然免疫，参与特异性免疫应答的启动，Toll样受体2(TLR2)作为一种重要跨膜Signal transduction受体参与了内毒素诱发炎症反应的病理过程，对其调控机制的研究日益受到关注。
Product Picture	Sample: Spleen(Mouse) Lysate at 40 ug Thymus (MouseLysate at 20 ug Primary: Anti-TLR2 (SL1019R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 84 kD Observed band size: 110 kD Sample: Raw264.7 (Mouse) Lysate at 30 ug Primary: Anti-TLR2 (SL1019R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 84 kD Observed band size: 104kD Sample: Lane 1: Spleen (Rat) Lysate at 40 ug Lane 2: Bronchus (Rat) Lysate at 40 ug Lane 3: Lung (Rat) Lysate at 40 ug Primary: Anti-TLR2 (SL1019R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 100 kD Observed band size: 98 kD Sample: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-TLR2 (SL1019R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 84 kD Observed band size: 95 kD Tissue/cell: rat ovary tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TLR2 Polyclonal Antibody, Unconjugated(SL1019R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TLR2) Polyclonal Antibody, Unconjugated (SL1019R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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