Product Name	ALDH1A1
Chinese Name	乙醛脱氢酶1型抗体
Alias	cytosolic; Acetaldehyde dehydrogenase 1; AHD2; Ahd-2; AL1A1_HUMAN; ALDC; Aldehyde dehydrogenase 1 family member A1; Aldehyde dehydrogenase 1 soluble; Aldehyde dehydrogenase 1A1; Aldehyde Dehydrogenase; Aldehyde dehydrogenase cytosolic; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase liver cytosolic; ALDH 1; ALDH 1A1; ALDH class 1; ALDH-E1; ALDH1 A1; ALDH1; ALDH11; ALHDII; MGC2318; PUMB1; RALDH 1; RalDH1; Retinal dehydrogenase 1; ALDEHYDE DEHYDROGENASE A1; Aldehyde Dehydrogenase Family 1, Subfamily A1.
literatures	Specific References  (8)     |     SL10162R has been referenced in 8 publications. [IF=43.474] Mingqian Fang. et al. Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms. IMMUNITY. 2023 Feb 27  WB ;  Mouse.   PubMed:36854305 [IF=8.755] Sijie Wang. et al. PFKFB4 facilitates palbociclib resistance in oestrogen receptor-positive breast cancer by enhancing stemness. CELL PROLIFERAT. 2022 Sep;:e13337  WB ;  Human.   PubMed:36127291 [IF=6.126] Chih-Wei Chou. et al. Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism. Cancers. 2020 Sep;12(9):2715  IF ;  Human.   PubMed:32971831 [IF=4.74] Qi et al. Sorting and identification of side population cells in the human cervical cancer cell line HeLa. (2014) Cancer.Cell.Int. 14:3  IHC ;  Human.   PubMed:24418020 [IF=4.486] Wang L et al. Lung CSC‐derived exosomal miR‐210‐3p contributes to a pro‐metastatic phenotype in lung cancer by targeting FGFRL1. J Cell Mol Med. 2020 Jun;24(11):6324-6339.  WB/IF ;  Human.   PubMed:32396269 [IF=2.93] Tang, Xin, et al. "Downregulation of CXCR7 inhibits proliferative capacity and stem cell-like properties in breast cancer stem cells." Tumor Biology (2016): 1-9.  WB ;   PubMed:27460092 [IF=2.642] Yohei Sekino. et al. BUB1B Overexpression Is an Independent Prognostic Marker and Associated with CD44, p53, and PD-L1 in Renal Cell Carcinoma. Oncology-Basel. 2021;99(4):240-250  IHC ;  Human.   PubMed:33588420 [IF=1.71] Luo, Chengxin, et al. "Upregulation of the transient receptor potential vanilloid 1 in colonic epithelium of patients with active inflammatory bowel disease." Int J Clin Exp Pathol 10.11 (2017): 11335-11344.  IHC-P ;  Human.   PubMed:ISSN:1936-2625/IJCEP0062035
Research Area	Tumour  Cell biology  immunology  Neurobiology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ALDH1: 201-300/501
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq] Function: Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Subunit: Homodimer. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in the liver, lung, and testis. Apparently not expressed at detectable levels in kidney, stomach, ovary, heart, and brain. Similarity: Belongs to the aldehyde dehydrogenase family. SWISS: P00352 Gene ID: 216 Database links: Entrez Gene: 216 Human Entrez Gene: 11668 Mouse Entrez Gene: 24188 Rat Entrez Gene: 443343 Sheep Omim: 100640 Human SwissProt: P00352 Human SwissProt: P24549 Mouse SwissProt: P51647 Rat SwissProt: P51977 Sheep Unigene: 76392 Human Unigene: 250866 Mouse Unigene: 6132 Rat
Product Picture	Sample: Placenta (Mouse) Lysate at 40 ug Primary: Anti-ALDH1 (SL10162R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kD Observed band size: 54 kD Sample: Liver (mouse) Lysate at 40 ug Primary: Anti- ALDH1 (SL10162R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kD Observed band size: 54 kD Sample: A549 Cell (Human) Lysate at 40 ug HepG2 Cell (Human) Lysate at 40 ug Primary: Anti-ALDH1(SL10162R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54kD Observed band size: 54kD Paraformaldehyde-fixed, paraffin embedded (human lung cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ALDH1) Polyclonal Antibody, Unconjugated (SL10162R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. Paraformaldehyde-fixed, paraffin embedded (human liver cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (ALDH1) Polyclonal Antibody, Unconjugated (SL10162R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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