Product Name	CXCR1
Chinese Name	细胞表面Chemokine受体1抗体
Alias	C C; C C CKR 1; CCCKR1; CD 181; CD128; CD181; CDw128a; Chemokine (C X C motif) receptor 1; Chemokine (C X C) receptor 1; Chemokine receptor 1; CKR 1; CMKAR1; CXCR 1; High affinity interleukin 8 receptor A; IL 8 receptor type 1; IL 8R A; IL-8RA; IL8 receptor; IL8 receptor type 1; IL8R1; IL8RA; IL8RBA; Interleukin 8 receptor alpha; Interleukin 8 receptor type 1. Interleukin 8 receptor type A; CXCR1_HUMAN; C-C; CD181; CKR-1; IL8R1; CDw128a; C-C-CKR-1.
literatures	Specific References  (6)     |     SL1009R has been referenced in 6 publications. [IF=8.786] Guangxu Xiao. et al. CXCR1 and its downstream NF-κB inflammation signaling pathway as a key target of Guanxinning injection for myocardial ischemia/reperfusion injury.. FRONT IMMUNOL. 2022 Oct;13:1007341-1007341  WB, IHC, IF ;  Mouse.   PubMed:36325326 [IF=3.37] Chengfei Xu. et al. CXCR1 participates in bone cancer pain induced by Walker 256 breast cancer cells in female rats. MOL PAIN. ;():  WB, IF ;  Rat.   PubMed:36227008 [IF=2.57] Schneberger, D., et al. "CXCR1/CXCR2 antagonist CXCL8 (3-74) K11R/G31P blocks lung inflammation in swine barn dust-instilled mice." Pulmonary Pharmacology & Therapeutics (2015).  IHC-P ;  Mouse.   PubMed:25681618 [IF=2.24] Tang, Cui, et al. "High expression of GPER1, EGFR and CXCR1 is associated with lymph node metastasis in papillary thyroid carcinoma." International Journal of Clinical and Experimental Pathology 7.6 (2014): 3213-3223.  IHC-P ;  Human.   PubMed:25031721 [IF=2.24] Tang et al. High expression of GPER1, EGFR and CXCR1 is associated with lymph node metastasis in papillary thyroid carcinoma. (2014) Int.J.Clin.Exp.Patho. 7:3213-23  IHC ;  Human.   PubMed:25031742 [IF=1.89] Zhao, Le, et al. "Role of GPER1, EGFR and CXCR1 in differentiating between malignant follicular thyroid carcinoma and benign follicular thyroid adenoma."International Journal of Clinical and Experimental Pathology 8.9 (2015): 11236-11247.  IHC-P ;  Human.   PubMed:26617848
Research Area	Tumour  immunology  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CXCR1: 186-280/350 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008] Function: Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25024 Gene ID: 3577 Database links: Entrez Gene: 3577 Human Entrez Gene: 227288 Mouse Entrez Gene: 54258 Rat Omim: 146929 Human SwissProt: P25024 Human SwissProt: Q810W6 Mouse SwissProt: P70612 Rat Unigene: 194778 Human Unigene: 337035 Mouse Unigene: 138115 Rat CXCR1主要表达于浸润的炎性细胞和肠epithelial cells表面.
Product Picture	Sample: Lane 1: Mouse Lymph node tissue lysates Lane 2: Rat Lymph node cell lysates Primary: Anti-CXCR1 (SL1009R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 45 kDa Sample: Lane 1: Mouse Lung tissue lysates Lane 2: Human Jurkat cell lysates Lane 3: Human Raji cell lysates Primary: Anti-CXCR1 (SL1009R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kDa Observed band size: 45 kDa Tissue/cell: rat colitis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CXCR1/IL-8RA Polyclonal Antibody, Unconjugated(SL1009R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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