Product Name	BMP6
Chinese Name	骨形态发生蛋白6抗体
Alias	Bone Morphogenic Protein 6; Decapentaplegic vegetal related; DVR6; BMP 6; BMP-6; TGFB related vegetal related growth factor; Transforming growth factor beta; Vegetal related (TGFB related) cytokine; Vg related sequence; VGR; VGR1; BMP6_HUMAN.
literatures	Specific References  (7)     |     SL10090R has been referenced in 7 publications. [IF=6.831] Hyun-Yi Kim. et al. Runx3 regulates iron metabolism via modulation of BMP signalling. 2021 Oct 06  IHC ;  Mouse.   PubMed:34611951 [IF=3.688] Jianshu Lv. et al. Regulatory role of dihydrotestosterone on BMP-6 receptors in granular cells of sheep antral follicles. Gene. 2021 Nov;:146066  WB,IF,IHC ;  Sheep.   PubMed:34838638 [IF=3.061] Wenju Liu. et al. High and low dose of luzindole or 4-phenyl-2-propionamidotetralin (4-P-PDOT) reverse bovine granulosa cell response to melatonin. PEERJ. 2023 Jan;11:e14612  WB ;  Bovine.   PubMed:36684672 [IF=2.923] Lei Wang. et al. BMP6 regulates AMH expression via SMAD1/5/8 in goat ovarian granulosa cells. THERIOGENOLOGY. 2022 Nov;:  IHC ;  Goat.   PubMed:36525856 [IF=1.554] Xiong Zitao. et al. Expression and localization of vitellogenin genes (VTG) and receptor (VGR) in the gonad development of silver pomfret Pampus argenteus. J OCEANOL LIMNOL. 2023 May;:1-18  IHC ;  Fish.   PubMed:10.1007/s00343-022-2016-2 [IF=1.487] Yuefeng Gaoet al. Vitamin E promotes ovine Sertoli cell proliferation by regulation of genes associated with cell division and the cell cycle. Anim Biotechnol . 2020 Jul 2;1-9.  WB ;  sheep.   PubMed:32615852 [IF=0.607] Yang F et al. Effect of Bone Morphogenetic Protein 6 (BMP6) on Chicken Granulose Cells Proliferation and Progesterone Synthesis. Brazilian Journal of Poultry Science.2019 Feb.  WB ;  Chicken.   PubMed:doi:10.1590/1806-9061-2018-0835
Research Area	Cell biology  Growth factors and hormones  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16/56kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BMP6: 421-513/513
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016] Function: Induces cartilage and bone formation. Subunit: Interacts with SOSTDC1. Subcellular Location: Secreted. Tissue Specificity: Expressed in the lung. Low levels seen in the kidney. Similarity: Belongs to the TGF-beta family. SWISS: P22004 Gene ID: 654 Database links: Entrez Gene: 654 Human Entrez Gene: 12161 Mouse Entrez Gene: 25644 Rat Omim: 112266 Human SwissProt: P22004 Human SwissProt: P20722 Mouse SwissProt: Q04906 Rat Unigene: 285671 Human Unigene: 385759 Mouse Unigene: 40476 Rat
Product Picture	Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti-BMP6 (SL10090R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 16/56 kD Observed band size: 76 kD Tissue/cell: mouse lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-BMP6 Polyclonal Antibody, Unconjugated(SL10090R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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