Product Name	SFTPC
Chinese Name	肺表面活性蛋白C抗体
Alias	PSP C; PSPC; Pulmonary surfactant apoprotein 2; pulmonary surfactant apoprotein PSP C; pulmonary surfactant associated protein C; pulmonary surfactant associated proteolipid SPL pVal; Pulmonary surfactant associated proteolipid SPL(Val); SFTP 2; SFTP2; SP-C; SFTPC surfactant pulmonary associated protein C; SP 5; SP C; SP5; SPC; surfactant associated protein pulmonary 2; Surfactant protein c; Surfactant pulmonary associated protein C; PSPC_HUMAN.
literatures	Specific References  (8)     |     SL10067R has been referenced in 8 publications. [IF=5.656] Kerr NA et al. Human Lung Cell Pyroptosis Following Traumatic Brain Injury. Cells. 2019 Jan 18;8(1). pii: E69.  FCM ;  Human.   PubMed:30669285 [IF=4.01] Yang et al. CXCR4 receptor overexpression in mesenchymal stem cells facilitates treatment of acute lung injury in rats. (2015) J.Biol.Chem. 290:1994-2006  other ;  Rat.   PubMed:25492872 [IF=3.84] Dinh, Phuong-Uyen C., et al. "Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies." Respiratory Research 18.1 (2017): 132.  FCM ;  Human.   PubMed:28666430 [IF=3.52] Yan, Wang, et al. "SB203580 inhibits epithelial–mesenchymal transition and pulmonary fibrosis in a rat silicosis model." Toxicology Letters (2016).  FCM ;  Rat.   PubMed:27480278 [IF=3.419] Shota Mitsuboshi. et al. A novel alveolar epithelial cell sheet fabricated under feeder-free conditions for potential use in pulmonary regenerative therapy. Regen Ther. 2022 Mar;19:113  IHC ;  Rat.   PubMed:10.1016/j.reth.2022.01.005 [IF=2.747] Lei Chen. et al. MiR-199a-3p in mouse bone marrow mesenchymal stem cell exosomes increases epithelial sodium channel expression in lung injury. FUND CLIN PHARMACOL. 2022 Jun 10  IF ;  Mouse.   PubMed:35667855 [IF=2.634] Liu X. et al. Effects of Different Ligands in the Notch Signaling Pathway on the Proliferation and Transdifferentiation of Primary Type II Alveolar Epithelial Cells.. Front Pediatr. 2020 Aug;8:452-452  WB ;  Rat.   PubMed:32850559 [IF=1.922] Ding et al. Glycogen synthase kinase‑3β inhibitor reduces LPS‑induced acute lung injury in mice. (2017) Mol.Med.Rep. 16:6715-6721  BALF ;  mouse.   PubMed:28901469
Research Area	Cell biology  immunology  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 Flow-Cyt=1μg/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	4/21kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SFTPC: 24-58/197
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified. Function: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. Subcellular Location: Secreted, extracellular space, surface film. DISEASE: Defects in SFTPC are the cause of pulmonary surfactant metabolism dysfunction type 2 (SMDP2) [MIM:610913]; also called pulmonary alveolar proteinosis due to surfactant protein C deficiency. A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPC are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS) [MIM:267450]; also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. Similarity: Contains 1 BRICHOS domain. SWISS: P11686 Gene ID: 6440 Database links: Entrez Gene: 6440 Human Entrez Gene: 20389 Mouse Omim: 178620 Human SwissProt: P11686 Human SwissProt: P21841 Mouse Unigene: 1074 Human Unigene: 24040 Mouse
Product Picture	Cell: NCI-H460 Concentration:1:100 Host/Isotype:Rabbit/IgG Flow cytometric analysis of Rabbit IgG isotype control (Cat#: SL10067R) on NCI-H460(green) compared with control in the absence of primary antibody (blue) followed by Alexa Fluor 488-conjugated goat anti-rabbit IgG(H+L) secondary antibody . Blank control（black line）:A549. Primary Antibody (green line): Rabbit Anti-SFTPC antibody (SL10067R)-PE Dilution:1ug/Test; Secondary Antibody : Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Negative control（white blue line）: PBS Isotype control（orange line）: Normal Rabbit IgG Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃, The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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