Product Name	Beta-casein
Chinese Name	β-酪蛋白抗体
Alias	Beta-casein; Casoparan; Antioxidant peptide; Casohypotensin; CASB; CASB_BOVIN; Casein beta; CSN 2; Csn2; CASB_BOVIN.
literatures	Specific References  (9)     |     SL10032R has been referenced in 9 publications. [IF=11.504] Sanam Foroutanparsa. et al. Spatial distribution of αs1-caseins and β-caseins in milk gels acidified with glucono-δ-lactone. FOOD HYDROCOLLOID. 2023 Jan;:108506  IF ;  Cow.   PubMed:10.1016/j.foodhyd.2023.108506 [IF=4.192] Chaochao Luo. et al. Glutamine Regulates Cell Growth and Casein Synthesis through the CYTHs/ARFGAP1-Arf1-mTORC1 Pathway in Bovine Mammary Epithelial Cells. J Agr Food Chem. 2021;XXXX(XXX):XXX-XXX  WB ;  Bovine.   PubMed:34096300 [IF=4.125] Minghui Zhang. et al. Comparative Transcriptomic Analysis of Mammary Gland Tissues Reveals the Critical Role of GPR110 in Palmitic Acid-Stimulated Milk Protein and Fat Synthesis. BRIT J NUTR. 2023 Mar;:1-32  WB ;  Mouse.   PubMed:36946032 [IF=3.86] Chu, Meiqiang, et al. "MicroRNA-126 participates in lipid metabolism in mammary epithelial cells." Molecular and Cellular Endocrinology (2017).  WB ;  Human.   PubMed:28599789 [IF=3.738] Zong, Jinxin. et al. Lithium Chloride Promotes Milk Protein and Fat Synthesis in Bovine Mammary Epithelial Cells via HIF-1α and β-Catenin Signaling Pathways. Biol Trace Elem Res. 2022 Jan;:1-16  WB ;  Bovine.   PubMed:35080710 [IF=3.412] Wang M et al. Protein 14-3-3ε Regulates Cell Proliferation and Casein Synthesis via PI3K-mTOR Pathway in Dairy Cow Mammary Epithelial Cells.(2018) J. Agric. Food Chem. Nov 14;66(45):12000-12008.  WB ;  Rat.   PubMed:30375228 [IF=2.75] Hou et al. Spleen tyrosine kinase regulates mammary epithelial cell proliferation in mammary glands of dairy cows. (2016) J.Dairy.Sci. 99:3858-68  WB ;  Bovine.   PubMed:26947307 [IF=2.718] Xiaoyu Duan. et al. mTORC2-AKT-LAT1 Signalling Participates in Methionine-induced β-CASEIN Expression in Mammary Epithelial Cells of Dairy Cows. J ANIM PHYSIOL AN N. 2023 Mar;:  WB ;  Bovine.   PubMed:36961053 [IF=2.705] Wang B et al. Laminin-dependent integrin β1 signaling regulates milk protein synthesis via prolactin/STAT5 pathway in bovine mammary epithelial cells. Biochem Biophys Res Commun. 2020 Jan 24.  WB ;  Bovine.   PubMed:31987497
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Cow, Goat,  (predicted: Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	24kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from cow Beta-casein: 16-100/224
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation Function: Important role in determination of the surface properties of the casein micelles. Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide. Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A. Antioxidant peptide has antioxidant activity. Subcellular Location: Secreted. Tissue Specificity: Mammary gland specific. Secreted in milk. Similarity: Belongs to the beta-casein family. SWISS: P11839 Gene ID: 443391 Database links: Entrez Gene: 1447 Human Entrez Gene: 281099 Bovin Entrez Gene: 443391 Sheep Omim: 115460 Human SwissProt: P05814 Human SwissProt: P02666 Bovin Unigene: 2242 Human
Product Picture	Sample: Lane 1: Milk (Cow) Lysate at 40 ug Primary: Anti-Beta-casein (SL10032R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 24 kD Sample: Lane 1: Milk (Goat) Lysate at 2 ug Lane 2: Milk (Cow) Lysate at 30 ug Lane 3: Milk (Cow) Lysate at 3 ug Lane 4: Milk (Human) Lysate at 30 ug Primary: Anti-Beta-casein (SL10032R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25-29 kD Observed band size: 25-29 kD

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Totalgoods,subtotals:￥Checkout