Product Name	MMP-20
Chinese Name	基质金属蛋白酶20抗体
Alias	Enamel metalloproteinase; Enamelysin; Matrix metalloproteinase 20; Matrix metalloproteinase 20 precursor; AI2A2; Matrix metalloproteinase-20; Matrix metalloproteinase 20 preproprotein; MMP 20; MMP-20; MMP20_HUMAN; MMP 20.
literatures	Specific References  (1)     |     SL0985R has been referenced in 1 publications. [IF=3.202] Aseervatham J et al. Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase-20 in human cancers. Cancer Med. 2019 Apr 1.  IHC-P,IF,PLA&WB ;  Human.   PubMed:30932369
Research Area	Tumour  Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	Extracellular matrix
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MMP20: 401-483/483
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	p65 is a subunit of the nuclear factor kappa-B, a second messenger, which activates the transcription of a number of genes in multiple tissues. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Active NF-kappa-B is a heterodimer of an about 50 kDa DNA-binding subunit and the weak DNA-binding subunit p65. Two heterodimers might form a labile tetramer. Subcellular location is at Nucleus, Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Tissue Specificity: Spleen; lower level in brain. Function: Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Subcellular Location: Secreted, extracellular space, extracellular matrix. Tissue Specificity: Expressed specifically in the enamel organ. Post-translational modifications: Autoactivates at least at the 107-Asn-|-Tyr-108 site. DISEASE: Amelogenesis imperfecta, hypomaturation type, 2A2 (AI2A2) [MIM:612529]: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. SWISS: O60882 Gene ID: 9313 Database links: Entrez Gene: 9313 Human Entrez Gene: 30800 Mouse Entrez Gene: 300341 Rat Omim: 604629 Human SwissProt: O60882 Human SwissProt: P57748 Mouse Unigene: 591946 Human Unigene: 390121 Mouse Unigene: 218697 Rat 基质金属蛋白酶20又称釉质溶解素
Product Picture	Tissue/cell: mouse spleen tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MMP-20 Polyclonal Antibody, Unconjugated(SL0985R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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