Product Name	LHR
Chinese Name	促黄体生成素受体抗体
Alias	LHCGR; Gonadotropin receptor; CGR; hCG receptor; FLJ41504; Gpcr19-rs1; GTHR-II; HHG; LCGR; LGR2; LH-R;LH/CG R; LH/CG-R; LH RECEPTOR; LH/CGR; LHRHR; LSH R; LSH-R; LSHR_MOUSE; Luteinizing hormone receptor; Luteinizing hormone/choriogonadotropin receptor; luteinizing hormone/choriogonadotropin receptor; Lutropin choriogonadotropic hormone receptor; Lutropin choriogonadotropic receptor; Lutropin-choriogonadotropic hormone receptor; ULG5.
literatures	Specific References  (2)     |     SL0984R has been referenced in 2 publications. [IF=6.71] Umehara, Takashi, et al. "The acceleration of reproductive aging in Nrg1flox/flox; Cyp19‐Cre female mice." Aging Cell (2017).  IHC-P ;  Mouse.   PubMed:28857490 [IF=4.161] Kinnear Hadrian M. et al. Presence of ovarian stromal aberrations after cessation of testosterone therapy in a transgender mouse model. BIOL REPROD. 2023 Feb;:  IHC ;  Mouse.   PubMed:36790125
Research Area	Neurobiology  Growth factors and hormones  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	76kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse CG Receptor: 501-600/700 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq] Function: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Gonadal and thyroid cells. DISEASE: Familial male precocious puberty (FMPP) [MIM:176410]: In FMPP the receptor is constitutively activated. Note=The disease is caused by mutations affecting the gene represented in this entry. Luteinizing hormone resistance (LHR) [MIM:238320]: An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. SWISS: P30730 Gene ID: 16867 Database links: Entrez Gene: 3973 Human Entrez Gene: 25477 Rat Omim: 152790 Human SwissProt: P22888 Human SwissProt: P16235 Rat Unigene: 468490 Human Unigene: 11216 Rat

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