Product Name	Neurogenin3
Chinese Name	神经元素3抗体
Alias	NGN3; NGN-3; neurogenin 3; Neurog3; Neurogenin-3; ATH4B; Atoh5; Math4B; NEUROG3; ngn3; OTTHUMP00000019730; Protein atonal homolog 5; Class A basic helix-loop-helix protein 7; NGN3_HUMAN.
literatures	Specific References  (2)     |     SL0922R has been referenced in 2 publications. [IF=2.08] Jian, Ruo-Lei, et al. "Generation of insulin-producing cells from C3H10T1/2 mesenchymal progenitor cells." Gene (2015).  WB ;  Mouse.   PubMed:25724395 [IF=0] Wenhuan Chai. et al. Visualizing Cathepsin K-Cre Expression at the Single-Cell Level with GFP Reporters. JBMR Plus. 2022 Dec;:e10706  IF ;  Mouse.   PubMed:36699636
Research Area	Cell biology  Neurobiology  Stem cells  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NGN3: 61-160/214
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm. Function: Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Subcellular Location: Nucleus. DISEASE: Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. Similarity: Contains 1 basic helix-loop-helix (bHLH) domain. SWISS: Q9Y4Z2 Gene ID: 50674 Database links: Entrez Gene: 50674 Human Entrez Gene: 11925 Mouse Entrez Gene: 60329 Rat Omim: 604882 Human SwissProt: Q9Y4Z2 Human SwissProt: P70661 Mouse Unigene: 532682 Human Unigene: 57236 Mouse Neurobiology相关蛋白（Neurobiology） Ngn3属于bHLH家族蛋白，是胰腺发育过程中短暂表达的蛋白，可能是胰腺内分泌细胞系的定向因子，一般在成熟胰岛中不存在。 Ngn3的表达会导致胰腺内分泌细胞数的增加外分泌细胞数的减少。因而胰岛β细胞并不是完全靠Stem cells分化产生，主要是通过已分化胰岛β细胞的分裂增殖。 但近年来，有学者认为：Ngn3虽在胰腺发育中短暂表达，但是否存在使胰岛Stem cells或前体细胞自我更新的能力尚未明确定论。
Product Picture	Sample:Liver(Mouse) Lysate at 30 ug Primary: Anti-Neurogenin3 (SL0922R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution Predicted band size: 23 kD Observed band size: 26 kD

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