Product Name	Insulin
Chinese Name	胰岛素抗体
Alias	ILPR; INS; Insulin A chain; Insulin B chain; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor; IDDM2; INS_HUMAN; MODY10.
literatures	Specific References  (10)     |     SL0862R has been referenced in 10 publications. [IF=10.273] Vlahos AE et al. Endothelialized collagen based pseudo-islets enables tuneable subcutaneous diabetes therapy. Biomaterials. 2019 Dec 26;232:119710.  ICF ;  Rat&Human.   PubMed:31901691 [IF=5.705] Sun HD et al. Electrochemical sandwich immunoassay for insulin detection based on the use of gold nanoparticle-modified MoS 2 nanosheets and the hybridization chain reaction. Microchimica Acta,2018 186(1).  sandwich immunoreaction ;   PubMed:10.1007/s00604-018-3124-8 [IF=4.927] Hany Ezzat Khalil. et al. Mechanistic Insights into the Ameliorative Effect of Cichoriin on Diabetic Rats—Assisted with an In Silico Approach. MOLECULES. 2022 Jan;27(21):7192  IHC ;  Rat.   PubMed:36364019 [IF=4.556] Hsiao-Pei Tsai. et al. Risperidone Exacerbates Glucose Intolerance, Nonalcoholic Fatty Liver Disease, and Renal Impairment in Obese Mice. Int J Mol Sci. 2021 Jan;22(1):409  IHC ;  Mouse.   PubMed:33401717 [IF=3.598] Xu X et al. Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers. Biofactors. 2019 May 23.  IHC-P ;  Mouse.   PubMed:31120577 [IF=3.412] Yuhua Gao. et al. Pancreatic Duct Cells Isolated From Canines Differentiate Into Beta-Like Pancreatic Islet Cells. Front Vet Sci. 2021; 8: 771196  IHC ;  Canine.   PubMed:35071380 [IF=3.216] Ji-sheng Wang. et al. Study on the Mechanism of Jiawei Shengjiang Powder in Improving Male Asthma-Induced Asthenospermia Based on Network Pharmacology and Bioinformatics. Drug Des Dev Ther. 2021 Mar;15:1245-1259  WB ;  Rat.   PubMed:33776422 [IF=2.634] Ma C et al. Identification and Multilineage Potential Research of a Novel Type of Adipose-Derived Mesenchymal Stem Cells from Goose Inguinal Groove. DNA Cell Biol. 2018 Sep;37(9):731-741.  ICF ;  Goose.   PubMed:30102556 [IF=1.918] Wang J et al. Effect of Asthma on Erectile Dysfunction in Rats as Determined by Biological Network AnalysisMed Sci Monit.2020 Dec 20;26:e927491.  WB ;  Rat.   PubMed:33341820 [IF=0.45] Xue, J. L., et al. "Distribution and Role of Receptor Interaction Protein 140 in Pancreatic β-Cells In Rodents, in vivo And in vitro." Acta Endocrinologica (Buc) 10.1 (2014): 41-52.  IHC-P ;  Mouse.   PubMed:10.4183/aeb.2014.41
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Signal transduction  Apoptosis  Growth factors and hormones  Diabetes  Endocrinopathy  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IP=1:20-100  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	5.77754kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	porcine pancreas ，full length
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma. Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds. Subcellular Location: Secreted. DISEASE: Hyperproinsulinemia, familial (FHPRI) [MIM:176730]: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material. Note=The disease is caused by mutations affecting the gene represented in this entry. Diabetes mellitus, insulin-dependent, 2 (IDDM2) [MIM:125852]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=The disease is caused by mutations affecting the gene represented in this entry. Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Note=The disease is caused by mutations affecting the gene represented in this entry. Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the insulin family. SWISS: P01315 Gene ID: 397415 Database links: Entrez Gene: 3630 Human Entrez Gene: 280829 Cow Entrez Gene: 16333 Mouse Entrez Gene: 16334 Mouse Entrez Gene: 24505 Rat Entrez Gene: 397415 Pig Omim: 176730 Human SwissProt: P01308 Human SwissProt: P01325 Mouse SwissProt: P01322 Rat SwissProt: P01315 Pig Unigene: 272259 Human 胰岛素（Insulin）是胰岛beta细胞分泌的一种激素，可以减低血糖浓度。此抗体特异性地识别猪胰岛素，并与人的胰岛素有React Species，主要用于胰岛细胞瘤的功能性研究。
Product Picture	Sample: Lane1：Islet A lysates at 20ug; line2,Islet B lysates at 20ug; Primary: Anti-Insulin (SL0862R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000 dilution; Predicted band size:5.8 kD Observed band size:5.8 kD

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