Product Name	IFNB1
Chinese Name	Interferonβ抗体
Alias	Interferon beta; Fibroblast interferon; IFB; IFF; IFN beta; IFN-Beta; IFNB 1; IFNB; Interferon beta 1 fibroblast; Interferon beta precursor; IFNB_HUMAN.  IFN-β; IFN β; β-IFN; IFB; β IFN; βIFN.
literatures	Specific References  (5)     |     SL0784R has been referenced in 5 publications. [IF=14.588] Hou L et al. Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy via Enhancing Innate Immunity. ACS Nano. 2020 Apr 28;14(4):3927-3940.   PubMed:3229807 [IF=13.273] Weihong Guo. et al. Improved immunotherapy for gastric cancer by nanocomposites with capability of triggering Dual-Damage of Nuclear/Mitochondrial DNA and cGAS/STING-Mediated innate immunity. CHEM ENG J. 2022 Sep;443:136428  WB ;  Mouse.   PubMed:10.1016/j.cej.2022.136428 [IF=5.195] Yuxi Liang. et al. The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway. J ETHNOPHARMACOL. 2023 Jan;300:115743  WB ;  Mouse.   PubMed:36152783 [IF=4.432] Pengfei Cheng. et al. A3 adenosine receptor agonist IB-MECA reverses chronic cerebral ischemia-induced inhibitory avoidance memory deficit. Eur J Pharmacol. 2022 Apr;921:174874  WB ;  Mouse.   PubMed:35278404 [IF=1.984] Liang Y et al. Astragalus Membranaceus Treatment Protects Raw264. 7 Cells from Influenza Virus by Regulating G1 Phase and the TLR3-Mediated Signaling Pathway. Evid Based Complement Alternat Med. 2019 Dec 31;2019:2971604.  WB ;  Mouse&canine.   PubMed:31975996
Research Area	Tumour  immunology  Bacteria and viruses  Interferon
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IFNB1: 101-184/184
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015] Function: Has antiviral, antibacterial and anticancer activities. Subunit: Monomer. Subcellular Location: Secreted. Similarity: Belongs to the alpha/beta interferon family. SWISS: P01575 Gene ID: 15977 Database links: Entrez Gene: 15977 Mouse SwissProt: P01575 Mouse Unigene: 1245 Mouse β型Interferon(Interferon-β,IFN-β)是主要由成纤维细胞产生的cell factor,属于单一基因编码产生的蛋白质,可通过干扰病毒RNA或DNA复制而抑制病毒生长,并可显著增强NK细胞杀伤活性,通过促进MHCⅠ类分子表达而增强CTL对病毒感染细胞的识别和杀伤作用.
Product Picture	Sample: Lane 1: Raw264.7 (Mouse) Cell Lysate at 30 ug Lane 2: THP-1 (Human) Cell Lysate at 30 ug Primary: Anti-IFN beta (SL0784R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 24 kD

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