Product Name	Livin
Chinese Name	凋亡抑制蛋白抗体
Alias	Baculoviral IAP repeat containing 7; Baculoviral IAP repeat containing protein 7; BIRC 7; BIRC7; BIRC7_HUMAN; KIAP; Kidney inhibitor of apoptosis protein; LIVIN; Livin inhibitor of apotosis; Melanoma inhibitor of apoptosis protein; ML IAP; MLIAP; RING finger protein 50; RNF 50; RNF50; Inhibitors of apoptosis proterins Livin.
literatures	Specific References  (1)     |     SL0738R has been referenced in 1 publications. [IF=0.13] Zhang, Z. J., et al. "Prospective experimental studies on the renal protective effect of ulinastatin after paraquat poisoning." World J Emerg Med 3.4 (2012): 299-304.  WB, IHC-P ;  Rat.   PubMed:25215081
Research Area	Tumour  Cell biology  Signal transduction  Apoptosis  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Livin: 101-200/298
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Livin is a novel member of the IAP protein family and contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin alpha and Livin beta. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. The two isoforms of Livin appear to have different functions and tissue distributions. Function: Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Subcellular Location: Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm. Tissue Specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. Similarity: Belongs to the IAP family. Contains 1 BIR repeat. Contains 1 RING-type zinc finger. SWISS: Q96CA5 Gene ID: 79444 Database links: Entrez Gene: 79444 Human Omim: 605737 Human SwissProt: Q96CA5 Human Unigene: 256126 Human Livin—属于凋亡蛋白抑制因子家族（inhibitor of apoptosis proteins，IAP） Livin是凋亡抑制蛋白家族的新成员，主要通过抑制Caspases蛋白发挥抑制Apoptosis的作用,主要在胎盘组织中表达，同时在一些Tumour组织中呈高表达，尤其是在黑色素瘤细胞系表达水平最高。 经研究表明，Livin与Tumour的发生、发展关系密切,是一个有潜在价值的TumourMaker，此外，反义Livin以及Livin活性抑制物的研究有望成为Tumour治疗的新靶点。
Product Picture	Sample:Lymph node (Mouse) Lysate at 40 ug Primary: Anti-Livin (SL0738R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33 kD Observed band size: 35 kD Tissue/cell: Human endometrium carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Livin Polyclonal Antibody, Unconjugated(SL0738R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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