Product Name	OAS1
Chinese Name	寡腺苷酸合成酶-1抗体
Alias	2',5'-oligoadenylate synthetase 1; (2 5')oligo(A) synthetase 1 ; (2 5')oligo(A) synthetase 1; 2 5 Oligoadenylate Synthetase 1; 2 5A synthetase 1; 2' 5' oligo A synthetase 1; 2' 5' oligoadenylate synthetase 1; 2' 5' oligoisoadenylate synthetase 1; 2'5' oligo A synthetase 1; 2'5' oligoadenylate synthetase 1; 2'5' oligoisoadenylate synthetase 1; E18/E16; IFI 4; IFI4; OAS 1; OIAS; OIASI; p46/p42 OAS; OAS1_HUMAN.
literatures	Specific References  (1)     |     SL0687R has been referenced in 1 publications. [IF=4.48] Xizhe Li. et al. Integrative bioinformatic analysis identified IFIT3 as a novel regulatory factor in psoriasis. J CELL BIOCHEM. 2022 Sep;:  IHC ;  Human.   PubMed:36169003
Research Area	Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40/46kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human OAS1: 1-100/400
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This protein is an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. Function: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Subunit: Monomer. Homotetramer. Subcellular Location: Cytoplasm. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum. Secreted. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. Similarity: Belongs to the 2-5A synthase family. SWISS: P00973 Gene ID: 4938 Database links: Entrez Gene: 347699 Cow Entrez Gene: 4938 Human Entrez Gene: 397570 Pig Entrez Gene: 192281 Rat Omim: 164350 Human SwissProt: P00973 Human SwissProt: P11928 Mouse SwissProt: Q29599 Pig SwissProt: Q05961 Rat Unigene: 524760 Human Unigene: 10383 Rat 用于免疫调控通路的研究。主要用于系统性红斑狼疮方面的研究。
Product Picture	Sample: Hela(Human) Cell Lysate at 40 ug Primary: Anti-OAS1 (SL0687R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40/46 kD Observed band size: 40 kD Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-OAS1 Polyclonal Antibody, Unconjugated(SL0687R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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