Product Name	GST1
Chinese Name	谷胱甘肽转移酶抗体
Alias	Glutathione S-Transferase Mu 1; Glutathione S-Transferase M1; GST HB Subunit 4; GST Class-Mu 1; EC 2.5.1.18; GSTM1a-1a; GSTM1b-1b; GSTM1-1; GST1; GTH4; S-(Hydroxyalkyl)Glutathione Lyase; Glutathione S-Aralkyltransferase; Glutathione S-Alkyltransferase; Glutathione S-Aryltransferase; HB Subunit 4; GTM1; MU-1; H-B; MU; GSTM1_HUMAN;
literatures	Specific References  (1)     |     SL0663R has been referenced in 1 publications. [IF=6.656] Simeng Chu. et al. Ursolic acid alleviates tetrandrine-induced hepatotoxicity by competitively binding to the substrate-binding site of glutathione S-transferases. PHYTOMEDICINE. 2022 Sep;104:154325  IF, WB ;  Mouse, Human.   PubMed:35820303
Research Area	Tumour  Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	26kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GST1: 151-218/218
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Subunit: Homodimer. Subcellular Location: Cytoplasm Tissue Specificity: Liver (at protein level). Similarity: Belongs to the GST superfamily. Mu family. SWISS: P09488 Gene ID: 2944 Database links: HGNC: 4632 Human Entrez Gene: 2944 Human Entrez Gene: 14862 Mouse UniProtKB: P09488 Human UniProtKB: P10649 Mouse OMIM: 138350 Human
Product Picture	Sample: HepG2(Human) Cell Lysate at 30 ug Hcclm3(Human) Cell Lysate at 30 ug Primary: Anti-GST1 (SL0663R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 26 kD Observed band size: 26 kD Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GST1) Polyclonal Antibody, Unconjugated (SL0663R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human liver tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GST1) Polyclonal Antibody, Unconjugated (SL0663R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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