Product Name	MRP3
Chinese Name	多药耐药相关蛋白3抗体
Alias	ABC 31; ABC31; ABCC 3; ABCC3; ATP binding cassette sub family C (CFTR/MRP) member 3; ATP binding cassette sub family C; ATP binding cassette sub family C member 3; Canalicular multispecific organic anion transporter 2; Canicular multispecific organic anion transporter; CMOAT 2; CMOAT2; EST90757; MLP 2; MLP2; MOAT D; MOATD; MRP 3; Multi specific organic anion transporter D; Multidrug resistance associated protein 3; Multidrug resistance associated protein; Multispecific organic anion tranporter D.
Research Area	Tumour
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	190kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MRP3: 1201-1300/1527 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MRP3 (Canalicular Multi Organic Anion Transporter 2 / Multidrug Resistance Associated Protein 3, cMOAT2) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. The specific function of MRP3 has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Function: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Mainly expressed in the liver. Also expressed in small intestine, colon, prostate, testis, brain and at a lower level in the kidney. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. SWISS: O15438 Gene ID: 8714 Database links: Entrez Gene: 8714 Human Entrez Gene: 76408 Mouse Entrez Gene: 140668 Rat Omim: 604323 Human SwissProt: O15438 Human SwissProt: B2RX12 Mouse SwissProt: O88563 Rat Unigene: 463421 Human Unigene: 23942 Mouse Unigene: 205054 Rat MRP3 (multidrug resistance protein 3)在正常epithelial cells：如；消化道，气管支气管，膀胱、肾上腺和睾丸组织中有不同的表达，在各种组织的基质细胞中也有程度不同的表达，在Tlymphocyte中表达较高，而原始造血Stem cells中则无表达。 MRP3又称ABCC3主要用于非PglycoproteinMDRTumour细胞系的Tumour耐药性的研究。 经研究发现MRP的同源性较高，他包括：MRP1、 MRP2、MRP3、MRP4和MRP5、MRP6和MRP7，都有部分交叉同源。

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