Product Name	IL13
Chinese Name	白介素13抗体
Alias	Interleukin-13; Interleukin 13; Interleukin13; ALRH; BHR 1; BHR1; IL 13; IL-13; MGC116786; MGC116788; MGC116789; NC30; P600; Interleukin-13; T-cell activation protein P600; IL13_MOUSE; IL13_HUMAN.
literatures	Specific References  (7)     |     SL0560R has been referenced in 7 publications. [IF=17.694] Glaubitz, Juliane. et al. In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response. NAT COMMUN. 2022 Aug;13(1):1-20  FC ;  Mouse.   PubMed:35922425 [IF=11.467] Yingzheng Zhao. et al. In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot. J CONTROL RELEASE. 2022 Oct;350:93  IHC ;  Rat.   PubMed:35973472 [IF=9.038] Bin Li. et al. lncRNA TUG1 as a ceRNA promotes PM exposure-induced airway hyper-reactivity. J Hazard Mater. 2021 Aug;416:125878  WB ;  Mouse.   PubMed:10.1016/j.jhazmat.2021.125878 [IF=5.249] Liang, Wei. et al. Polarized M2 macrophages induced by mechanical stretching modulate bone regeneration of the craniofacial suture for midfacial hypoplasia treatment. 2021 Sep 27  WB ;  Rat.   PubMed:10.1007/s00441-021-03533-5 [IF=3.115] Jing L et al. Srolo Bzhtang, a traditional Tibetan medicine formula, inhibits cigarette smoke induced airway inflammation and muc5ac hypersecretion via suppressing IL-13/STAT6 signaling pathway in rats. J Ethnopharmacol. 2019 May 10;235:424-434.  IHC-P&WB ;  Rat.   PubMed:30731182 [IF=1.785] Ying Xue. et al. Application of TGF‑β1, TIMP‑1 and TIMP‑2 small interfering RNAs can alleviate CCl4‑induced hepatic fibrosis in rats by rebalancing Th1/Th2 cytokines. Exp Ther Med. 2021 Sep;22(3):1-7  WB,IHC ;  Rat.   PubMed:34335905 [IF=1.55] Yang, Lijuan, et al. "Effect of IL-17 in the development of colon cancer in mice." Oncology Letters 12.6 (2016): 4929-4936.  WB ;  Mouse.   PubMed:28101230
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	12kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IL-13: 45-56/131(mo)
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Subcellular Location: Secreted. DISEASE: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Similarity: Belongs to the IL-4/IL-13 family. SWISS: P20109 Gene ID: 16163 Database links: Entrez Gene: 3596 Human Entrez Gene: 16163 Mouse Entrez Gene: 116553 Rat Omim: 147683 Human SwissProt: P35225 Human SwissProt: P20109 Mouse SwissProt: P42203 Rat Unigene: 845 Human Unigene: 1284 Mouse Unigene: 9921 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IL-13) Polyclonal Antibody, Unconjugated (SL0560R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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