Product Name	Mitofusin 1
Chinese Name	Mitochondrion融合蛋白1抗体
Alias	Mitofusin 1; Fzo homolog; MFN 1; Mitochondrial transmembrane GTPase Fzo 1; Mitochondrial transmembrane GTPase FZO 2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin 1; Mitofusin1; Putative transmembrane GTPase; Transmembrane GTPase MFN1; MFN1_HUMAN; Mitofusin-1.
literatures	Specific References  (9)     |     SL0557R has been referenced in 9 publications. [IF=6.792] Yang Q et al. Hexavalent chromium induces mitochondrial dynamics disorder in rat liver by inhibiting AMPK/PGC-1α signaling pathway. Environ Pollut.2020 Oct;265(Pt A):114855.  WB ;  Rat.   PubMed:32474337 [IF=6.513] Zhe Li. et al. Bisphenol A aggravate selenium deficiency-induced apoptosis via miR-215-3p/Dio1 to activate ROS/PI3K/AKT pathway in chicken arterial. J CELL PHYSIOL. 2023 Apr;:  WB ;  Chicken.   PubMed:37012668 [IF=5.895] Xixi Wang. et al. Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis. J AGR FOOD CHEM. 2023;XXXX(XXX):XXX-XXX  WB ;  Mouse,Rat.   PubMed:37010249 [IF=5.572] Chengcheng Peng. et al. Crosstalk between Mfn2-mediated mitochondria associated membranes disorder and autophagy induced by molybdenum and cadmium in sheep heart. FOOD CHEM TOXICOL. 2023 Apr;174:113660  WB ;  Sheep.   PubMed:36803920 [IF=4.527] Wang S et al. Hydrogen sulfide-induced oxidative stress leads to excessive mitochondrial fission to activate apoptosis in broiler myocardia. Ecotoxicol Environ Saf. 2019 Aug 20;183:109578.  WB ;  broiler.   PubMed:31442807 [IF=4.099] Lu Yiming. et al. Cadmium induces apoptosis of pig lymph nodes by regulating the PI3K/AKT/HIF-1α pathway. Toxicology. 2021 Mar;451:152694  WB ;  Pig.   PubMed:33493553 [IF=3.7] Ku, Tingting, et al. "PM 2.5, SO 2 and NO 2 co-exposure impairs neurobehavior and induces mitochondrial injuries in the mouse brain."Chemosphere 163 (2016): 27-34.  WB ;  Mouse.   PubMed:27521637 [IF=2.835] Yuan Zhang a et al. Electroacupuncture ameliorates endotoxin-induced acute lung injury in rabbits by regulating heme oxygenase-1 expression to improve mitochondrial dynamics. Journal of King Saud University – Science, 2019.  WB ;  Rabbit.   PubMed:DOI:10.1016/j.jksus.2019.11.029 [IF=1.96] Qing, Shuang-Li, et al. "The decreased expression of mitofusin-1 and increased fission-1 together with alterations in mitochondrial morphology in the kidney of rats with chronic fluorosis may involve elevated oxidative stress." Journal of Trace Elements in Medicine and Biology (2014).  IHC-P ;  Rat.   PubMed:24958380
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Apoptosis  The new supersedes the old  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Mfn 1: 651-741/741
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Mitofusin 1 (Mfn1) and mitofusin 2 (Mfn2) are homologs for the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins and are mediators of mitochondrial fusion. A GTPase domain is required for Mfn protein function but the molecular mechanisms of the GTPase-dependent reaction as well as the functional division of the two Mfn proteins are unknown. They are essential for embryonic development and may play a role in the pathobiology of obesity. Although the Mfn1 and Mfn2 genes are broadly expressed, they show different levels of expression in different tissues. Two Mfn1 transcripts are elevated in heart, while Mfn2 mRNA is abundantly expressed in heart and muscle tissue but present only at low levels in many other tissues. Mfn1 localizes to mitochondria and participates in at least two different high molecular weight protein complexes in a GTP-dependent manner. Purified recombinant Mfn1 exhibited approximately eightfold higher GTPase activity than Mfn2. Function: Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks. Subunit: Forms homomultimers and heteromultimers with MFN2. Multimerization, which is mediated by the second coiled coil region, may play an essential role in mitochondrion fusion. Participates in a high molecular weight multiprotein complex. Interacts with VAT1. Subcellular Location: Cytoplasm and Mitochondrion outer membrane. Tissue Specificity: Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers. Post-translational modifications: Ubiquitinated by MARCH5. Similarity: Belongs to the mitofusin family. SWISS: Q8IWA4 Gene ID: 55669 Database links: Entrez Gene: 55669 Human Entrez Gene: 67414 Mouse Entrez Gene: 192647 Rat Omim: 608506 Human SwissProt: Q8IWA4 Human SwissProt: Q811U4 Mouse SwissProt: Q8R4Z9 Rat Unigene: 478383 Human Unigene: 290414 Mouse Unigene: 160939 Rat Mitochondrion融合蛋白1具有促进Mitochondrion融合、抑制细胞增殖、保护细胞免于凋亡等多种功能。
Product Picture	Blank control: RSC96(blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 1μg in 100 μL1X PBS containing 0.5% BSA(green).

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