Product Name	Interferon alpha 2b
Chinese Name	Interferonα2b抗体
Alias	Interferon alpha-2b; Alpha 2a interferon; alpha-2a interferon; IFN alpha 2b; IFNA 2; IFNA; INFA 2; INFA2; Interferon alpha 2; Interferon alpha 2 precursor; Interferon alpha 8 precursor; Interferon alpha A; Interferon alpha B; Interferon alpha B2; Interferon alpha-2 precursor; LeIF A; LeIF B; LeIFA; MGC125764; Interferon alpha B; Interferon alpha B2; interferon, alpha 8; LeIF B; MGC125765; IFN-alpha-2; IFNA2_HUMAN; MGC125765.
literatures	Specific References  (1)     |     SL0536R has been referenced in 1 publications. [IF=1.797] Shaaban R et al. Molecular and Biological Characterization of a Prepared Recombinant Human Interferon Alpha 2b Isoform.(2018) Appl. Biochem. Biotechnol. 2018 Oct 18.  WB ;  Rat.   PubMed:30334171
Research Area	Tumour  Cell biology  immunology  glycoprotein  cell factor  Interferon
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	19kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IFN alpha 2b
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Interferon alpha 2b is one of the known 23 different variants of IFN-alpha. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxy-terminal end. Interferon alpha 2b is a potent immune modulator. It can either inhibit or enhance immune cell activity within the tightly regulated microenvironment of inflammation, depending upon the concentration of the cytokine and the activation stage of the cell. Interferon alpha 2B is currently used as an anticancer drug due to it's antiproliferative activity. Function: Produced by macrophages, IFN-alpha have antiviral activities. Subunit: Interacts with IFNAR2. Subcellular Location: Secreted. Similarity: Belongs to the alpha/beta interferon family. SWISS: P01563 Gene ID: 3440 Database links: Entrez Gene: 3440 Human Omim: 147562 Human SwissProt: P01563 Human Unigene: 211575 Human
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Interferon alpha 2b) Polyclonal Antibody, Unconjugated (SL0536R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: mouse liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IFN-Alpha 2b/Interferon alpha 2/INFA2 Polyclonal Antibody, Unconjugated (SL0536R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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