Product Name	MMP7
Chinese Name	基质金属蛋白酶-7抗体
Alias	Matrilysin; Matrilysin uterine; Matrin; Matrix Metalloproteinase 7; MMP-7; MMP 7; MMP7; MPSL1; PUMP 1; Pump 1 protease; PUMP1; Uterine Matrilysin; Uterine metalloproteinase; MMP7_HUMAN.
literatures	Specific References  (10)     |     SL0423R has been referenced in 10 publications. [IF=9.075] Li, Jun. et al. Immunoproteasome inhibition prevents progression of castration-resistant prostate cancer. BRIT J CANCER. 2023 Jan;:1-14  IHC,IF ;  Mouse,Human.   PubMed:36681728 [IF=6.832] Wu, Haibin. et al. Dextran sulfate prevents excess aggregation of human pluripotent stem cells in 3D culture by inhibiting ICAM1 expression coupled with down-regulating E-cadherin through activating the Wnt signaling pathway. STEM CELL RES THER. 2022 Dec;13(1):1-20  WB ;  Human.   PubMed:35619172 [IF=4.848] Wang Chengqin. et al. Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling. Front Oncol. 2021 Jan;10:3063  WB,IHC ;  Human.   PubMed:33542902 [IF=4.17] Madka, Venkateshwar, et al. "TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma." American Journal of Cancer Research 5.10 (2015): 3030.  WB ;  Mouse.   PubMed:26693057 [IF=4.162] Wenwen Chen. et al. Identification of Active Compounds and Mechanism of Huangtu Decoction for the Treatment of Ulcerative Colitis by Network Pharmacology Combined with Experimental Verification. Drug Des Dev Ther. 2021; 15: 4125–4140  IHC ;  mouse.   PubMed:34616145 [IF=3.89] Jeinsen, Niklas, et al. "Biocompatibility of intensified decellularized equine carotid arteries in a rat subcutaneous implantation model and in a human in vitro-model." Tissue Engineering (2017).  IF(ICC) ;  Human.   PubMed:28530164 [IF=3.86] Wu, Bo. et al. Diagnostic values of plasma matrix metalloproteinase-7, interleukin-8, and gamma-glutamyl transferase in biliary atresia. EUR J PEDIATR. 2022 Sep;:1-9  IF ;  Human.   PubMed:36094664 [IF=3.73] Zhu, Hongwu, et al. "Activating Transcription Factor 4 Promotes Esophageal Squamous Cell Carcinoma Invasion and Metastasis in Mice and Is Associated with Poor Prognosis in Human Patients." PloS one 9.7 (2014): e103882.  IHC-P ;  Human.   PubMed:25078779 [IF=2.146] Lv Y et al. TGF-β1 enhanced myocardial differentiation through inhibition of the Wnt/β-catenin pathway with rat BMSCs. Iran J Basic Med Sci . 2020 Aug;23(8):1012-1019.  WB ;  Rat.   PubMed:32952947 [IF=2.146] Yang Lv. et al. TGF-β1 enhanced myocardial differentiation through inhibition of the Wnt/β-catenin pathway with rat BMSCs. Iran J Basic Med Sci. 2020 Aug; 23(8): 1012–1019  WB ;  Rat.   PubMed:32952947
Research Area	Tumour  immunology  Neurobiology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	30kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MMP7: 151-250/269
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] Function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. Subcellular Location: Secreted, extracellular space, extracellular matrix (Probable). Similarity: Belongs to the peptidase M10A family. SWISS: P09237 Gene ID: 4316 Database links: Entrez Gene: 4316 Human Entrez Gene: 17393 Mouse Entrez Gene: 25335 Rat Omim: 178990 Human SwissProt: P09237 Human SwissProt: Q10738 Mouse SwissProt: P50280 Rat Unigene: 2256 Human Unigene: 4825 Mouse Unigene: 10282 Rat Synthesis and Degradation（Synthesis and Degradation） MMP7属于MMP基因家族的成员之一，MMP-7又称溶基质蛋白素(Matrilysin)，其主要功能为降解粘蛋白、纤维连结蛋白和层粘连蛋白，在Tumour细胞突破基底膜屏障和浸润、转移中起重要作用。目前主要用于各种恶性Tumour(如乳腺癌、胃肠道癌、卵巢癌、膀胱癌等)转移、浸润的研究及用于机体各种组织的发育和修复、Tumour发生发展、炎症反应等过程中作用的研究。
Product Picture	Sample: Uterus (Mouse) Lysate at 30 ug Primary: Anti- MMP-7 (SL0423R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kD Observed band size: 34 kD Sample: Lymph node(Rat) Lysate at 40 ug Liver (Mouse) Lysate at 40 ug Primary: Anti-MMP7 (SL0423R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kD Observed band size: 30 kD Sample: Lane 1: Uterus (Mouse) Lysate at 40 ug Lane 2: Lung (Mouse) Lysate at 40 ug Primary: Anti- MMP7 (SL0423R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 27 kD Observed band size: 27 kD

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