Product Name	PIBF
Chinese Name	孕激素诱导阻断因子抗体
Alias	progesterone induced blocking factor; KIAA1008; PIBF 1; PIBF; PIBF1; Progesterone immunomodulatory binding factor 1; Progesterone induced blocking factor 1; PIBF1_HUMAN; RP11 505F3.1; CEP90; C13orf24; RP11-505F3.1.
Research Area	immunology  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	83kDa
Cellular localization	The nucleus Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PIBF: 551-650/756
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	C13orf24 is also known as Progesterone-induced-blocking factor 1 (PIBF1). PIBF1 is synthesized by lymphocytes of healthy pregnant women in the presence of progesterone and inhibits arachidonic acid release, by acting on the phospholipase A2 enzyme, inducing a Th2 biased immune response. It also controls NK activity, and modifies the cytokine balance exerting an anti-abortive effect. Function: Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect. Tissue Specificity: Expressed at highest levels in testis. Moderate expression is detected in spleen, thymus, prostate, ovary, small intestine, and colon. SWISS: Q8WXW3 Gene ID: 10464 Database links: Entrez Gene: 10464 Human Entrez Gene: 52023 Mouse Entrez Gene: 306104 Rat Omim: 607532 Human SwissProt: Q8WXW3 Human Unigene: 441926 Human 孕激素诱导阻断因子又称孕酮诱导的封闭因子性蛋白。 妊娠期间lymphocyte生成孕酮受体且释放一种称之为孕酮诱导的封闭因子性蛋白(PIBF),PIBF有很强的抗NK细胞活性,PIBF阳性lymphocyte分泌IL-10。
Product Picture	Sample: Testis (Mouse) Lysate at 40 ug Testis (Rat) Lysate at 40 ug Primary: Anti-PIBF (SL0420R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 83 kD Observed band size: 83 kD Tissue/cell: Rat testis tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PIBF Polyclonal Antibody, Unconjugated(SL0420R) 1:500, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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