Product Name	TIMP-2
Chinese Name	金属蛋白酶组织抑制因子-2抗体
Alias	Metalloproteinase inhibitor 2 precursor; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor; CSC 21K; CSC21K; TIMP2; TIMP 2; TIMP 2; TIMP metallopeptidase inhibitor 2; TIMP2_HUMAN; Metalloproteinase inhibitor 2; CSC-21K; TIMP-2.
literatures	Specific References  (12)     |     SL0416R has been referenced in 12 publications. [IF=5.064] Xia Liu. et al. The adipokine orosomucoid alleviates adipose tissue fibrosis via the AMPK pathway. Acta Pharmacol Sin. 2021 Apr;:1-9  WB ;  Mouse.   PubMed:33875797 [IF=3.53] Lu HY, Huang CY, Shih CM, Chang WH, Tsai CS, et al. (2015) Dipeptidyl Peptidase-4 Inhibitor Decreases Abdominal Aortic Aneurysm Formation through GLP-1-Dependent Monocytic Activity in Mice. PLoS ONE 10(4): e0121077.  IHC-P ;  Mouse.   PubMed:25876091 [IF=3.361] Varghese S et al. Immunostimulatory plant polysaccharides impede cancer progression and metastasis by avoiding off-target effects. Int Immunopharmacol. 2019 May 21;73:280-292.  WB ;  Human.   PubMed:31125927 [IF=3.31] Watts, Ryan P., et al. "Novel 24-h ovine model of brain death to study the profile of the endothelin axis during cardiopulmonary injury." Intensive Care Medicine Experimental 3.1 (2015): 31.  IHC-P ;   PubMed:26596583 [IF=3.14] Varghese, Sheeja, et al. "The inhibitory effect of anti-tumor polysaccharide from Punica granatum on metastasis." International Journal of Biological Macromolecules (2017).  WB ;  Human.   PubMed:28552725 [IF=2.92] He, Qiaowei, et al. "Single minded 2-s (SIM2-s) gene is expressed in human GBM cells and involved in GBM invasion." Cancer Biology & Therapy 9.6 (2010): 430-436.  WB ;  Human.   PubMed:20448453 [IF=2.53] Ni, Wei-Jian, et al. "Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats." European journal of pharmacology 764 (2015): 448-456.  WB, IHC-P ;  Rat.   PubMed:26192633 [IF=2.25] Shi S et al. MicroRNA-34a attenuates VEGF-mediated retinal angiogenesis via targeting the Notch1.(2018) Biochemistry and Cell Biology  WB ;  Rat &Human.   PubMed:30571142 [IF=2.247] Tort S et al. The effect of a new wound dressing on wound healing: Biochemical and histopathological evaluation. Burns. 2019 Dec 17. pii: S0305-4179(18)30976-8.  IHC-P ;  Rat.   PubMed:31862280 [IF=1.91] Fang, Ming, Xin-Chi Wu, and Wenlong Huang. "Raloxifene Upregulated Mesangial Cell MMP-2 Activity via ER-?? Through Transcriptional Regulation."Cell Biochemistry and Biophysics (2013): 1-7..  WB ;  Mouse.   PubMed:23471663 [IF=1.841] Ozge Petek Erpolat. et al. Angiotensin-converting Enzyme Inhibitor Reduces Radiation-induced Periprosthetic Capsular Fibrosis. J Surg Res. 2021 Jul;263:167  IHC ;  Rat.   PubMed:33667872 [IF=1.719] Saribas GS et al. Effects of uterus derived mesenchymal stem cells and their exosomes on asherman's syndrome. Acta Histochem. 2019 Nov 24:151465.  IHC-P ;  Rat.   PubMed:31776004
Research Area	Tumour  Cardiovascular  Cell biology  Neurobiology  Signal transduction  Apoptosis  Growth factors and hormones  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	24kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TIMP-2: 131-220/220
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]. Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Subunit: Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity. Subcellular Location: Secreted. Post-translational modifications: The activity of TIMP2 is dependent on the presence of disulfide bonds. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P16035 Gene ID: 7077 Database links: Entrez Gene: 282093 Cow Entrez Gene: 100135629 Guinea pig Entrez Gene: 7077 Human Entrez Gene: 21858 Mouse Entrez Gene: 100008689 Rabbit Entrez Gene: 29543 Rat Omim: 188825 Human SwissProt: P16368 Cow SwissProt: Q9WUC6 Guinea pig SwissProt: P16035 Human SwissProt: P25785 Mouse SwissProt: Q9TRZ7 Rabbit SwissProt: P30121 Rat Unigene: 633514 Human Unigene: 206505 Mouse Unigene: 10161 Rat Synthesis and Degradation（Synthesis and Degradation） TIMP-2与TIMP-1一样是基质金属蛋白酶的抑制酶，其功能与MMP相反，能抑制Tumour细胞的浸润和转移，主要用于各种恶性Tumour如乳腺癌等的研究。TIMP-2又称为CSC-21K，是一种21-24kDa的glycoprotein，在多种组织细胞中表达，它可以和MMPs家族成员以共价键方式形成复合物，从而发挥其抑制作用。在正常生理条件下，MMPs和TIMPs之间的平衡状态是维持Extracellular matrix正常状态所必需的，一旦它们之间的比例失调，就会造成一系列的病理状态。

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