Product Name	PLGF
Chinese Name	胎盘生长因子抗体
Alias	Placenta growth factor; PGF; PGFL; PIGF; Placental growth factor vascular endothelial growth factor related protein; PlGF 2; PLGF; PlGF2; PLGF_MOUSE; Vascular endothelial growth factor related protein.
literatures	Specific References  (4)     |     SL0280R has been referenced in 4 publications. [IF=13.352] Guangdong Bai. et al. Perinatal exposure to glyphosate-based herbicides impairs progeny health and placental angiogenesis by disturbing mitochondrial function. ENVIRON INT. 2022 Dec;170:107579  WB ;  Pig.   PubMed:36265358 [IF=3.24] Enoch Odame Anto. et al. Placental lesions and differential expression of pro-and anti-angiogenic growth mediators and oxidative DNA damage marker in placentae of Ghanaian suboptimal and optimal health status pregnant women who later developed preeclampsia. Plos One. 2022 Mar;17(3):e0265717  IHC ;  Human.   PubMed:35312727 [IF=2.7] Zhang, Liang, et al. "Placenta growth factor contributes to cell apoptosis and epithelial-to-mesenchymal transition in the hyperoxia-induced acute lung injury." Life Sciences (2016).  WB ;  Rat.   PubMed:27211521 [IF=2.47] Zhang, Liang, et al. "Knockdown of placental growth factor (PLGF) mitigates hyperoxia-induced acute lung injury in neonatal rats: Suppressive effects on NFκB signaling pathway." International Immunopharmacology 38 (2016): 167-174.  WB ;  Rat.   PubMed:27280587
Research Area	Tumour  Cell biology  immunology  Neurobiology  Growth factors and hormones  transcriptional regulatory factor  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Mouse, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse PLGF: 101-158/158
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011] Function: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Subunit: Antiparallel homodimer; disulfide-linked. Also found as heterodimer with VEGFA/VEGF. Subcellular Location: Secreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin. Tissue Specificity: While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas. Post-translational modifications: N-glycosylated. Similarity: Belongs to the PDGF/VEGF growth factor family. SWISS: P49764 Gene ID: 18654 Database links: Entrez Gene: 5228 Human Entrez Gene: 18654 Mouse Entrez Gene: 94203 Rat Omim: 601121 Human SwissProt: P49763 Human SwissProt: P49764 Mouse SwissProt: Q63434 Rat Unigene: 252820 Human Unigene: 4809 Mouse Unigene: 6960 Rat PLGF胎盘生长因子是血管生长因子家族成员之一（又称：胎盘型vascular endothelial cell生长因子），是动脉粥样硬化斑块不稳定的主要炎性激活物，因此它可作为ACS患者风险预测的生物学Maker.尿胎盘生长因子水平可预测先兆子痫危险.研究人员发现，在疾病发作前的6到8周，先兆子痫患者尿液中的胎盘生长因子水平急剧下降,这种新的尿检方法使提前1到2个月预测先兆子痫成为可能。亦有研究人员正在从事胎盘生长因子与肺气肿，胃癌，肠癌等方面的研究。
Product Picture	Sample: Placenta (Rat) Lysate at 30 ug Primary: rabbit Anti-PLGF (SL0280R) at 1:300 dilution; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000 dilution; Predicted band size:16 kD Observed band size:16 kD

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