Product Name	Osteopontin
Chinese Name	骨桥蛋白/分泌型磷蛋白1抗体
Alias	BNSP; Bone sialoprotein 1; BSP I; BSPI; Early T lymphocyte activation 1; ETA 1; ETA1; MGC110940; Nephropontin; OPN; osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein; OSTP_HUMAN; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1); Secreted phosphoprotein 1; SPP 1; SPP-1; SPP1; SPP1/CALPHA1 fusion; Urinary stone protein; Uropontin.
literatures	Specific References  (6)     |     SL0019R has been referenced in 6 publications. [IF=3.539] Shunli Feng. et al. SPP1 as a key gene in the lymph node metastasis and a potential predictor of poor prognosis in head and neck carcinoma. J ORAL PATHOL MED. 2022 Jul 13  WB, IHC ;  Human.   PubMed:35822409 [IF=3.23] Liu C, Zhang Y, Wang L, Zhang X, Chen Q, Wu B (2015) A Strontium-Modified Titanium Surface Produced by a New Method and Its Biocompatibility In Vitro. PLoS ONE 10(11): e0140669.  WB ;  Rat.   PubMed:26529234 [IF=3.08] Zhan, Fu‐Liang, Xin‐Yang Liu, and Xing‐Bo Wang. "The Role of MicroRNA‐143‐5p in the Differentiation of Dental Pulp Stem Cells into Odontoblasts by Targeting Runx2 via the OPG/RANKL Signaling Pathway." Journal of Cellular Biochemistry (2017).  WB ;  Human.   PubMed:28608628 [IF=2.766] Li et al. Visfatin Destabilizes Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice. (2016) PLoS.One. 11:e0148273  IF ;  Rat.   PubMed:26848572 [IF=2.538] Xinxin Yu. et al. OPN up-regulated proliferation and invasion of HNSCC through p38MAPK signaling pathway. OR SURG OR MED OR PA. 2023 Mar;:  WB,IHC ;  Human.   PubMed:10.1016/j.oooo.2023.03.003 [IF=0] Wei, Min Jun, et al. "Identification of OPN, TNC and E-selectin as potential recognition proteins in cerebral vasospasm after subarachnoid hemorrhage."Chinese Neurosurgical Journal 2.1 (2016): 1.  WB, IHC-P ;  Rat.   PubMed:10.1186/s41016-016-0035-6
Research Area	immunology  Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human OPN: 141-220/314
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Osteopontin is the principal phosphorylated glycoprotein of bone and is expressed in a limited number of other tissues including dentine. Osteopontin is produced by osteoblasts under stimulation by calcitriol and binds tightly to hydroxyapatite. It is also involved in the anchoring of osteoclasts to the mineral of bone matrix via the vitronectin receptor, which has specificity for osteopontin. Osteopontin is overexpressed in a variety of cancers, including lung, breast, colorectal, stomach, ovarian, melanoma and mesothelioma. Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity). Subunit: Ligand for integrin alpha-V/beta-3. Subcellular Location: Secreted. Tissue Specificity: Bone. Found in plasma. Similarity: Belongs to the osteopontin family. SWISS: P10451 Gene ID: 6696 Database links: Entrez Gene: 6696 Human Entrez Gene: 20750 Mouse Entrez Gene: 25353 Rat Omim: 166490 Human SwissProt: P10451 Human SwissProt: P10923 Mouse SwissProt: P08721 Rat Unigene: 313 Human Unigene: 288474 Mouse Unigene: 8871 Rat 信号传导（Signaling Intermediates） 骨桥蛋白(osteopontin，OPN)是一种含精氨酸—甘氨酸—天冬氨酸(Arg-Gly-Asp，RGD)的分泌型糖基化磷蛋白，已归类于Extracellular matrix(extracellular matrix，ECM)蛋白。 OPN既是cell factor，又是细胞黏附分子.又称：分泌性磷酸化蛋白质1 OPN最初是从骨组织分离的，而后在epithelial cells、胃肠道的分泌物、肾、甲状腺、睾丸以及一些Tumour细胞里都陆续的发现了OPN的表达。在生殖方面，OPN在分泌期子宫内膜epithelial cells、侵袭的滋养细胞、蜕膜细胞中表达。
Product Picture	Sample: A549 Cell Lysate at 40 ug Primary: Anti-ostepontin (SL0019R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 50 kD

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