Product Name	IGF 1
Chinese Name	胰岛素样生长因子1抗体
Alias	IBP1; IGF 1; IGF I; IGF-1;IGF IA; IGF IB; IGF1; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C); Full=Insulin-like growth factor I; Insulin Like Growth Factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Mechano growth factor; MGF; Mechano growth factor; MGF; Somatomedia C; Somatomedin C; IGF1_HUMAN.  IGF-I;
literatures	Specific References  (27)     |     SL0014R has been referenced in 27 publications. [IF=8.307] Yue Wang. et al. Potential use of bioactive nanofibrous dural substitutes with controlled release of IGF-1 for neuroprotection after traumatic brain injury. NANOSCALE. 2022 Nov;:  IF ;  Human.   PubMed:36468670 [IF=8.025] Qinqin Hu. et al. An injectable thermosensitive Pluronic F127/hyaluronic acid hydrogel loaded with human umbilical cord mesenchymal stem cells and asiaticoside microspheres for uterine scar repair. INT J BIOL MACROMOL. 2022 Jul;:  IF ;  Rat.   PubMed:35902020 [IF=7.666] Ryo Honma. et al. Immunomodulatory Macrophages Enable E-MNC Therapy for Radiation-Induced Salivary Gland Hypofunction. CELLS-BASEL. 2023 Jan;12(10):1417  ICC,IHC ;  Mouse.   PubMed:10.3390/cells12101417 [IF=6.575] Qiyu Gan. et al. Prognostic Value and Immune Infiltration of HPV-Related Genes in the Immune Microenvironment of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma. CANCERS. 2023 Jan;15(5):1419  IHC ;  Human.   PubMed:36900213 [IF=6.208] Akihito Sotome. et al. Spinal Canal and Spinal Cord in Rat Continue to Grow Even after Sexual Maturation: Anatomical Study and Molecular Proposition. INT J MOL SCI. 2022 Jan;23(24):16076  WB ;  Rat.   PubMed:36555713 [IF=5.201] Li Taotao. et al. Unraveling Stage-Dependent Expression Patterns of Circular RNAs and Their Related ceRNA Modulation in Ovine Postnatal Testis Development. Front Cell Dev Biol. 2021 Mar;9:650  IF ;  Sheep.   PubMed:33816472 [IF=5.201] Li Taotao. et al. Unraveling Stage-Dependent Expression Patterns of Circular RNAs and Their Related ceRNA Modulation in Ovine Postnatal Testis Development. Front Cell Dev Biol. 2021 Mar;9:650  WB ;  Sheep.   PubMed:33816472 [IF=4.268] Qin Yang. et al. Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7/IGF1R-mediated programmed cell death and inflammation. Phytomedicine. 2021 Mar;:153541  WB ;  Human.   PubMed:33773190 [IF=3.598] Li R et al. Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses. Biofactors. 2019 Oct 24.  IHF&ICF ;  Human.   PubMed:31647596 [IF=3.553] Man Luo. et al. miR136 regulates proliferation and differentiation of small tail han sheep preadipocytes. ADIPOCYTE. 2023;12(1):Article: 2173966  WB ;  Sheep,Human.   PubMed:36722834 [IF=3.36] Zhao L et al. Reducing macrophage numbers alleviates temporomandibular joint ankylosis. Cell Tissue Res. 2019 Sep 14.  IHC ;  Human.   PubMed:31522279 [IF=3.335] XuTing Song. et al. Molecular cloning, expression, and functional features of IGF1 splice variants in sheep. Endocr Connect. 2021 Jul;-1(aop):  WB ;  Sheep.   PubMed:34319906 [IF=2.985] Ito E et al. Food restriction reduces cortical bone mass and serum insulin-like growth factor-1 levels and promotes uterine atrophy in miceBiochem Biophys Res Commun.2021 Jan 1;534:165-171.  IHC ;  Mouse.   PubMed:33288195 [IF=2.948] Nevin Ersoy. et al. The Effects of Prenatal and Postnatal Exposure to 50-Hz and 3 mT Electromagnetic Field on Rat Testicular Development. MED LITH. 2023 Jan;59(1):71  IHC ;  Rat.   PubMed:36676695 [IF=2.564] Balogh O et al. Expression of insulin-like growth factor 1 and its receptor in preovulatory follicles and in the corpus luteum in the bitch. Gen Comp Endocrinol. 2018 Dec 1;269:68-74.  IHC-P ;  Dog.   PubMed:30125572 [IF=2.466] Cemile Merve Seymen. et al. Involvement of endometrial IGF-1R/IGF-1/Bcl-2 pathways in experimental polycystic ovary syndrome: Identification of the regulatory effect of melatonin. Tissue Cell. 2021 Jun;:101585  WB,IHC ;  Rat.   PubMed:10.1016/j.tice.2021.101585 [IF=2.08] Yokohira M et al. Lung proliferative lesion‐promoting effects of left pulmonary ligation in A/J female mice. Pathol Int. 2020 Feb 21.  IHC-P ;  Mouse.   PubMed:32083387 [IF=2.005] Yongfu La. et al. Different expression of LHR, PRLR, GH and IGF1 during testicular development of yak. 2021 Nov 09  WB ;  Yak.   PubMed:34752661 [IF=1.97] Liao et al. The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation. (2018) Arch.Med.Sci. 14:370-380  IHC ;  Rat.   PubMed:29593812 [IF=1.812] Liao, Wei-Tao, et al. "The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation." (2016).  IHC-P ;  Rat.   PubMed:29593812 [IF=1.8] Uysal, Nazan, et al. "Exercise increases leptin levels correlated with IGF-1 in hippocampus and prefrontal cortex of adolescent male and female rats." Journal of Chemical Neuroanatomy (2017).  IHC-P ;  Rat.   PubMed:28179125 [IF=1.422] Muller et al. Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs. (2017) Reprod.Domest.Anim. 52 Suppl 2:187-192  IHC ;  Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,.   PubMed:28101891 [IF=1.386] Yingchao Shen. et al. Proteomic differences between the ovulatory and anovulatory sides of the mare's follicular and oviduct fluid. J EQUINE VET SCI. 2022 Dec;:104207  WB ;  Horse.   PubMed:36592664 [IF=1.21] Müller, L., et al. "Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs." Reproduction in Domestic Animals (2017).  IHC-P ;  Dog.   PubMed:10.1111/rda.12896 [IF=1.06] Kiray, M., et al. "Effects of carbon dioxide exposure on early brain development in rats." Biotechnic & Histochemistry 0 (2014): 1-13.  IHC-P ;  Rat.   PubMed:24476563 [IF=1.06] Baykara, B., et al. "Progesterone treatment decreases traumatic brain injury induced anxiety and is correlated with increased serum IGF-1 levels; prefrontal cortex, amygdala, hippocampus neuron density; and reduced serum corticosterone levels in immature rats." Biotechnic & Histochemistry 0 (2013): 1-8.  Rat.   PubMed:23480228 [IF=0.48] Gabr, Hala, et al. "The effect of bone marrow‐derived mesenchymal stem cells on chemotherapy induced ovarian failure in albino rats." Microscopy Research and Technique (2016).  IHC-P ;  Rat.   PubMed:27453009
Research Area	immunology  Developmental biology  Signal transduction  Growth factors and hormones  Diabetes
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat, Dog,  (predicted: Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	7.7/21kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IGF-1: 49-100/195
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Subcellular Location: Secreted. DISEASE: Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Similarity: Belongs to the insulin family. SWISS: P05019 Gene ID: 3479 Database links: Entrez Gene: 3479 Human Omim: 147440 Human SwissProt: P05019 Human Unigene: 160562 Human 胰岛素样生长因子1(IGF-1)是一种生长调节激素，由肝分泌并入血液循环的中性多肽，具有调节生长和代谢、胰岛素样及促细胞分裂的活性，主要作用于成人。
Product Picture	Sample: Lane 1: Human IGF1 protein (full length) Overexpression E.coli Lysate at 4 ug Lane 2: Control (-) E.coli Lysate at 4 ug Primary: Anti-IGF 1 (SL0014R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 21 kD Observed band size: 21 kD Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IGF 1) Polyclonal Antibody, Unconjugated (SL0014R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Mouse trachea); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IGF) Polyclonal Antibody, Unconjugated (SL0014R) at 1:2000 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (rat uterus); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IGF 1) Polyclonal Antibody, Unconjugated (SL0014R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (IGF 1) Polyclonal Antibody, Unconjugated (SL0014R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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