TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-PDE9A/Biotin Chinese Name 生物素标记的磷酸二酯酶9A抗体 Alias 5''-cyclic phosphodiesterase 9A; cGMP specific 3' 5' cyclic phosphodiesterase type 9; CGMP-specific 3'5'-cyclic phosphodiesterase type 9; FLJ90181; High affinity cGMP-specific 3''; High-affinity cGMP-specific 3'5'-cyclic phosphodiesterase 9A; HSPDE9A2; OTTHUMP00000109399; PDE 9A; Pde9a; PDE9A_HUMAN; Phosphodiesterase 9A; phosphodiesterase PDE9A21. Research Area Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Pig, Cow, Sheep, ) Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 70-73kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PDE9A Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.
Subcellular Location:
Cytoplasm. Endoplasmic reticulum; Cell projection > ruffle membrane. Cytoplasm > perinuclear region and Cell projection > ruffle membrane. Cytoplasm > perinuclear region. Golgi apparatus. Endoplasmic reticulum.
Tissue Specificity:
Expressed in all tissues examined (testis, brain, small intestine, skeletal muscle, heart, lung, thymus, spleen, placenta, kidney, liver, pancreas, ovary and prostate) except blood. Highest levels in brain, heart, kidney, spleen, prostate and colon. Isoform PDE9A12 is found in prostate.
Similarity:
Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily.
Database links:Entrez Gene: 5152 Human
Entrez Gene: 18585 Mouse
GenBank: NP_001001567.1 Human
Omim: 602973 Human
SwissProt: O76083 Human
SwissProt: O76083-2 Human
SwissProt: O70628 Mouse
Unigene: 473927 Human
Unigene: 10812 Mouse
Unigene: 20981 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode