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Product Name Anti-PREB/Biotin Chinese Name 生物素标记的催乳素调节元件Binding proteinPREB抗体 Alias Mammalian guanine nucleotide exchange factor mSec12; Preb; PREB_HUMAN; Prolactin regulatory binding element protein; Prolactin regulatory element binding; Prolactin regulatory element binding protein; Prolactin regulatory element-binding protein; SEC12. Research Area Cell biology Developmental biology Growth factors and hormones transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Sheep, ) Applications WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 45kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PREB Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]
Function:
Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.
Subcellular Location:
Nucleus. Endoplasmic reticulum membrane.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 3 WD repeats.
Database links:Entrez Gene: 10113 Human
Entrez Gene: 50907 Mouse
Omim: 606395 Human
SwissProt: Q9HCU5 Human
SwissProt: Q9WUQ2 Mouse
Unigene: 279784 Human
Unigene: 272414 Mouse
Unigene: 41899 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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