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Product Name Anti-AD7c-NTP/AP Chinese Name 碱性磷酸酶(AP)标记的神经丝蛋白单克隆抗体 Alias neuronal thread protein AD7c-NTP; AD7c-NTP. Research Area Neurobiology Signal transduction Apoptosis Immunogen Species Mouse Clonality Monoclonal Clone NO. 2F5 React Species (predicted: Human, ) Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 41kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen Recombinant human AD7C NTP full length protein Lsotype IgG1 Purification affinity purified by Protein G Storage Buffer Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene is unusual in that its coding sequence is derived almost entirely from a cluster of different Alu repeat sequences. However, the mRNA and the encoded protein have been shown to be expressed in neurons, and overexpressed in brains with Alzheimer's disease. In vitro studies also demonstrated that abnormal expression of this gene promoted neuritic sprouting and cell death, associated with dementia in Alzheimer's disease.
Database links:GenBank: AAC08737
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AD7C-NTP是存在于神经元中的一种41Kda的蛋白质,在AD患者脑内选择性升高,和其病理过程相关,AD7C-NTP基因也只在神经元表达,AD患者脑脊液中AD7C-NTP表达升高, AD7C-NTP作为AD早期诊断和确诊的生物化学标志正引起越来越多的关注.
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