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Rabbit Anti-RSF1/AP Conjugated antibody
Rabbit Anti-RSF1/AP Conjugated antibody
HXBAP; p325; RSF1_HUMAN;remodeling and spacing factor 1; RSF 1; XAP8.
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  • NO.:SL18867R-AP
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)
    Applications:WB IHC-P IHC-F ICC
    concentration:1mg/ml
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Details

Product Name Anti-RSF1/AP
Chinese Name 碱性磷酸酶(AP)标记的RSF1蛋白抗体
Alias HXBAP; p325; RSF1_HUMAN; remodeling and spacing factor 1; RSF 1; XAP8.  
Research Area Tumour  Cell biology  Signal transduction  The new supersedes the old  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 164kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human RSF1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]

Function:
Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX transcription activator. In case of infection by HBV, together with pX, it represses TNF-alpha induced NF-kappa-B transcription activation. Represses transcription when artificially recruited to chromatin by fusion to a heterogeneous DNA binding domain.

Subunit:
Interacts with SMARCA5/SNF2H to form the RSF complex. Also binds the HBV pX/HBx protein, which is required to activate transcription of the viral genome.

Subcellular Location:
Nucleus

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Contains 1 DDT domain.
Contains 1 PHD-type zinc finger.

Database links:

Entrez Gene: 51773 Human

Entrez Gene: 476797 Dog

Entrez Gene: 233532 Mouse

Omim: 608522 Human

SwissProt: Q96T23 Human

Unigene: 420229 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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