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Product Name Anti-GPCR GPR87/AP Chinese Name 碱性磷酸酶(AP)标记的G protein-coupled receptor87抗体 Alias FKSG 78; FKSG78; G protein coupled receptor 87; G protein coupled receptor 95; G-protein coupled receptor 87; G-protein coupled receptor 95; GPCR87; GPR 87; GPR 95; GPR87; GPR87_HUMAN; GPR95; hGPCR87; KPG 002; KPG_002; MGC131898; Orphan GPCR 87; Probable G protein coupled receptor 87, Research Area Tumour Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 41kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPCR GPR87 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a G protein-coupled receptor and is located in a cluster of G protein-couple receptor genes on chromosome 3. The encoded protein has been shown to be overexpressed in lung squamous cell carcinoma (PMID:18057535) and regulated by p53 (PMID:19602589). [provided by RefSeq, Nov 2011]
Function:
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 53836 Human
Entrez Gene: 84111 Mouse
Omim: 606379 Human
SwissProt: Q9BY21 Human
SwissProt: Q99MT7 Mouse
Unigene: 591292 Human
Unigene: 60267 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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