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Product Name Anti-ECO1/AP Chinese Name 碱性磷酸酶(AP)标记的ECO1蛋白抗体 Alias A930014I12Rik; CTF; CTF7 homolog 1; CTF7, S. cerevisiae, homolog of, 1; ECO1; ECO1 homolog 1; ECO1, S. cerevisiae, homolog of, 1; EFO1; EFO1p; ESCO1; ESCO1_HUMAN; ESO1; ESO1 homolog 1; ESO1, S. pombe, homolog of, 1; Establishment factor like protein 1; Establishment factor ortholog 1; Establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; Establishment of cohesion 1, S. cerevisiae, homolog of; establishment of sister chromatid cohesion N-acetyltransferase 1; hEFO1; HGNC:24645; KIAA1911; N acetyltransferase ESCO1; Research Area Cell biology Chromatin and nuclear signals Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 95kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ECO1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
EFO1 is responsible for coupling cohesion and DNA replication processes thereby ensuring proper pairing of sister chromatids. EFO1 is phosphorylated during mitosis and this may act to regulate EFO1 activity. Due to alternative splicing events, three EFO1 isoforms exist.
Function:
Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
Subcellular Location:
Nucleus. Chromosome. Nuclear at interphase, associated with chromosomes during mitosis.
Tissue Specificity:
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
Post-translational modifications:
Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the acetyltransferase family. GCN5 subfamily.
Database links:Entrez Gene: 114799 Human
Entrez Gene: 77805 Mouse
Omim: 609674 Human
SwissProt: Q5FWF5 Human
SwissProt: Q69Z69 Mouse
Unigene: 464733 Human
Unigene: 210996 Mouse
Unigene: 450684 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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